Fig. 3
From: MRI for assessment of pathologic nipple discharge: is it mandatory?
A 52-year-old female patient with bleeding from left nipple. a Mammography in craniocaudal view shows focal asymmetry in the left retroareolar region with grouped microcalcifications (black arrow) that show segmental distribution. b B-mode ultrasound shows mottled parenchyma in the left upper outer quadrant (black arrow). c T2, STIR, and contrast-enhanced T1 images; T2 image shows moderate glandular breast parenchyma while STIR image shows low SI area in the upper outer quadrant extending from the retroareolar region to the posterior third of the breast. It shows non-mass enhancement after IV contrast administration with segmental distribution (black arrow). d Histopathology revealed high-grade ductal carcinoma in situ with focus of microinvasion in the form of nodule of invading neoplastic cells (not exceeding 1.0 mm) into the periductal stroma, associated with fibroblast proliferation, collagenisation and focal inflammation