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Table 4 Showing results and comparison of previous studies

From: Proton MR spectroscopy in characterization of focal bone lesions of peripheral skeleton

Ref. no.Sample sizeInclusionsSVS/MVS,
TE (ms)
Scanner
Choline quantification methodResultsComparison with the present study
Aggarwal S et al. 2014 (3)30Bone and soft tissue lesions,
mainly soft tissue masses
SVS
40,135,270
1.5 T
Cho/SNR > 2 in at least two TEsSensitivity 60%
Specificity 93.3%
PPV 90%
NPV 70%
Accuracy 76.6%
Concluded that MRS is a promising adjunct tool.
Similar conclusions.
Wang et al. 2004 (5)36Both bone (15) and soft tissue (21) massesSVS
40,135,270
1.5 T
Qualitative,
choline peak on spectra at least two TEs
Choline found in 18/19 malignant tumors.
Sensitivity 95%
Specificity 82%
Very similar results
Zhang et al. 2013 (6)83Only bone tumorsSVS
110
1.5 T
Semiquantitative
Cho:lipid ratio ≥ 0.2 was positive result
Concluded that MRS can help in differentiating benign and malignant bone tumors.
Sensitivity 76%
Specificity 88%
Similar conclusions.
Zi-Hua QI et al. 2009 (7)56Both bone and soft tissue tumorsSVS
144
3 T
Semi-Quantitative,
Cho/Cr ratios
Cho/Cr ratios were significantly higher in malignant lesions.
Sensitivity 94%
Specificity 83%
PPV 92%
NPV 88%
Sensitivity, specificity similar.
PPV, NPV probably different because of the semi-quantitative method.
Fayad LM, Wang X et al. 2010 (9)34Bone and soft tissue lesions.SVS
135
3 T
Quantitative,
Cho concentrations calculated
Choline present in all 3 pre-treatment malignant lesions.
Choline concentration was different in benign and malignant.
Similar results.
Patni.et.al.2017
(12)
42Patients undergoing MRI for musculoskeletal tumorsMVS
135
QuantitativeCho/Cr ratios were significantly higher in malignant lesions.Statistical significance seen between Cho/Cr ratio and histological grade of the tumor.
Fayad LM, Blumke DA et al. 2006 (13)13Resected specimens of bone sarcomasMVS
280
1.5 T
Semi-quantitative
Cho/SNR ratio
All bone sarcomas showed choline peak which was much higher than normal marrow.Similar results, Concluded that choline can be used as a marker for malignancy in bone tumors.
Fayad LM, Barker PB 2006 (14)23 lesions in 18 patientsBone (6 patients) and soft tissue lesions (12 patients)SVS (20) + MVS(3)
144
3 T
Semiquantitative,
Cho/SNR ratios
Choline peak present in all pretreatment malignant cases.
Mean Cho/SNR ratios in malignant and benign lesions was different
Similar results.
Lee CW et al. 2009
(15)
27Both bone and soft tissue tumors.
19 malignant and 8 benign lesions.
SVS
144
3 T
Quantitative
Cho concentration calculated.
Sensitivity 68.4%
Specificity 87.5%
Concluded that low-grade malignancies have a may false-negative result on MRS
Similar conclusions
S. Doganay et al. 2011 (16)30Bone or soft tissue tumors.SVS
31,136,272
1.5 T
Qualitative
Cho peak on spectra from at least two TEs
Concluded that MRS may be a useful tool.
Sensitivity 72.2%.
Specificity 83.3%
Similar conclusions.
Teixeria PAG et al.
2017
(17)
76 lesions in 74 patientsBoth bone and soft tissue tumors.
28 bone tumors, 15 malignant.
SVS
144 TE
3 T
QualitativeDid not recommend MRS for characterization.
Sensitivity 46.7%
Specificity 61.5%
For bone tumors.
Different results.
Selection bias possible