Table 4 Showing results and comparison of previous studies
From: Proton MR spectroscopy in characterization of focal bone lesions of peripheral skeleton
Ref. no. | Sample size | Inclusions | SVS/MVS, TE (ms) Scanner | Choline quantification method | Results | Comparison with the present study |
|---|---|---|---|---|---|---|
Aggarwal S et al. 2014 (3) | 30 | Bone and soft tissue lesions, mainly soft tissue masses | SVS 40,135,270 1.5 T | Cho/SNR > 2 in at least two TEs | Sensitivity 60% Specificity 93.3% PPV 90% NPV 70% Accuracy 76.6% Concluded that MRS is a promising adjunct tool. | Similar conclusions. |
Wang et al. 2004 (5) | 36 | Both bone (15) and soft tissue (21) masses | SVS 40,135,270 1.5 T | Qualitative, choline peak on spectra at least two TEs | Choline found in 18/19 malignant tumors. Sensitivity 95% Specificity 82% | Very similar results |
Zhang et al. 2013 (6) | 83 | Only bone tumors | SVS 110 1.5 T | Semiquantitative Cho:lipid ratio ≥ 0.2 was positive result | Concluded that MRS can help in differentiating benign and malignant bone tumors. Sensitivity 76% Specificity 88% | Similar conclusions. |
Zi-Hua QI et al. 2009 (7) | 56 | Both bone and soft tissue tumors | SVS 144 3 T | Semi-Quantitative, Cho/Cr ratios | Cho/Cr ratios were significantly higher in malignant lesions. Sensitivity 94% Specificity 83% PPV 92% NPV 88% | Sensitivity, specificity similar. PPV, NPV probably different because of the semi-quantitative method. |
Fayad LM, Wang X et al. 2010 (9) | 34 | Bone and soft tissue lesions. | SVS 135 3 T | Quantitative, Cho concentrations calculated | Choline present in all 3 pre-treatment malignant lesions. Choline concentration was different in benign and malignant. | Similar results. |
Patni.et.al.2017 (12) | 42 | Patients undergoing MRI for musculoskeletal tumors | MVS 135 | Quantitative | Cho/Cr ratios were significantly higher in malignant lesions. | Statistical significance seen between Cho/Cr ratio and histological grade of the tumor. |
Fayad LM, Blumke DA et al. 2006 (13) | 13 | Resected specimens of bone sarcomas | MVS 280 1.5 T | Semi-quantitative Cho/SNR ratio | All bone sarcomas showed choline peak which was much higher than normal marrow. | Similar results, Concluded that choline can be used as a marker for malignancy in bone tumors. |
Fayad LM, Barker PB 2006 (14) | 23 lesions in 18 patients | Bone (6 patients) and soft tissue lesions (12 patients) | SVS (20) + MVS(3) 144 3 T | Semiquantitative, Cho/SNR ratios | Choline peak present in all pretreatment malignant cases. Mean Cho/SNR ratios in malignant and benign lesions was different | Similar results. |
Lee CW et al. 2009 (15) | 27 | Both bone and soft tissue tumors. 19 malignant and 8 benign lesions. | SVS 144 3 T | Quantitative Cho concentration calculated. | Sensitivity 68.4% Specificity 87.5% Concluded that low-grade malignancies have a may false-negative result on MRS | Similar conclusions |
S. Doganay et al. 2011 (16) | 30 | Bone or soft tissue tumors. | SVS 31,136,272 1.5 T | Qualitative Cho peak on spectra from at least two TEs | Concluded that MRS may be a useful tool. Sensitivity 72.2%. Specificity 83.3% | Similar conclusions. |
Teixeria PAG et al. 2017 (17) | 76 lesions in 74 patients | Both bone and soft tissue tumors. 28 bone tumors, 15 malignant. | SVS 144 TE 3 T | Qualitative | Did not recommend MRS for characterization. Sensitivity 46.7% Specificity 61.5% For bone tumors. | Different results. Selection bias possible |