Table 1 Molecular classification of breast carcinoma [13]
Feature | Luminal A | Luminal B | HER-2+ | Basal like |
|---|---|---|---|---|
ER/PR | Positive | Positive | Mostly negative | Negative |
HER-2 | Negative | May be amplified | Amplified | Negative |
Other markers’ positivity | CK 8/18 | CK 8/18 | Androgen receptor | CK 5/6, EGFR |
Proliferation rate (ki67 index) | Low | Intermediate | High | Very high |
Recommended therapy | Hormonal | Hormonal and chemotherapy | Herceptin and chemotherapy | Chemotherapy |
Prognosis | Favorable | Unfavorable | Poor | Worst |