Table 1 Nottingham combined histologic grade (Zbytek et al., 2013)
From: Correlative study between ADC value and grading of invasive breast cancer
Score | Tubular formation | |
1 | More than 75% of the tumor has tubule formation | |
2 | 10% to 75% of the tumor has tubule formation | |
3 | Less than 10% of the tumor has tubule formation | |
Score | Nuclear pleomorphism | |
1 | Nuclei are small and uniform in size and shape | |
2 | Nuclei are moderate in nuclear size and variation | |
3 | Nuclei have marked variation, are relatively large, and have prominent or multiple nucleoli | |
Score | Mitotic count (per 10 high-power fields) | |
1 | 0–9 mitoses | |
2 | 10–19 mitoses | |
3 | ≥ 20 mitoses | |
Grade | Differentiation status | Total score |
1 | Well-differentiated | 3–5 points |
2 | Moderately differentiated | 6–7 points |
3 | Poorly differentiated | 8–9 points |