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Table 1 Nottingham combined histologic grade (Zbytek et al., 2013)

From: Correlative study between ADC value and grading of invasive breast cancer

ScoreTubular formation
  1More than 75% of the tumor has tubule formation
  210% to 75% of the tumor has tubule formation
  3Less than 10% of the tumor has tubule formation
ScoreNuclear pleomorphism
  1Nuclei are small and uniform in size and shape
  2Nuclei are moderate in nuclear size and variation
  3Nuclei have marked variation, are relatively large, and have prominent or multiple nucleoli
ScoreMitotic count (per 10 high-power fields)
  10–9 mitoses
  210–19 mitoses
  3≥ 20 mitoses
GradeDifferentiation statusTotal score
  1Well-differentiated3–5 points
  2Moderately differentiated6–7 points
  3Poorly differentiated8–9 points