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Table 1 Clinical characteristics of the children diagnosed with ANEC

From: Multi-parametric magnetic resonance imaging in acute necrotizing encephalopathy of children: validity and prognostic value

Stages NO. of cases %
1st stage (prodromal stage)
 Respiratory manifestations (e.g., cough/expectoration) 10 33.3%
 GIT manifestations (e.g., vomiting, diarrhea) 6 20%
 Skin manifestations (e.g., erythema) 2 7%
 Fever associated with the previous manifestations 14 47%
 Non-specific febrile illness 12 40%
2nd stage (acute necotizing encephalopathy stage/neurological manifestations)
 Generalized convulsions 18 60%
 Abnormal movements/agitated 14 46.6%
 Disturbed consciousness 18 60%
 Focal deficits 24 80%
 Weak lower limbs 6 20%
 Dysarthria 4 13.3%
 Behavioral changes 8 26.7%
 Diplopia 6 20%
3rd stage (prognosis/follow-up)
 Survived with neurological sequelae 20 67%
 Full recovery 6 20%
 Died 4 13%