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Table 5 Sensitivities, specificities, and accuracies expressed per regions involved

From: Whole body diffusion-weighted MRI in detection of metastasis and lymphoma: a prospective longitudinal clinical study

  Positive Negative Sensitivity Specificity PPV NPV Accuracy
TP FP TN FN Value 95% CI Value 95% CI Value 95% CI Value 95% CI Value 95% CI
LNs (16 regions) 2 × Cervical 26 13 44 9 74 57–88 77 64–87 67 54–77 83 73–90 76 66–84
Mediastinal 10 5 21 10 50 27–73 81 61–93 67 45–83 68 57–77 67 52–80
2 × supra-clavicular 8 7 67 10 44 22–69 91 81–96 53 32–73 87 81–91 82 72–89
2 × axillary 27 18 42 5 84 67–95 70 57–81 60 50–69 89 79–95 75 65–83
Para-aortic 16 1 27 2 89 65–98 96 82–100 94 70–99 93 78–98 93 82–99
Porta-hepatis 9 0 36 1 90 56–100 100 90–100 100   97 85–100 98 88–100
Mesenteric 8 3 32 3 73 39–94 91 77–98 73 46–89 91 80–97 87 74–95
2 × iliac 19 5 63 5 79 58–93 93 84–98 79 61–90 93 85–97 89 81–95
2 × femoral 12 9 71 0 100 74–100 89 80–95 57 42–71 100   90 82–95
2 × inguinal 19 18 54 1 95 75–100 75 63–84 51 41–61 98 89–100 79 70–87
Total LNs 154 79 457 46 77 71–83 85 82–88 66 61–71 91 88–93 83 80–86
Skeletal system (63 regions) Skull 11 1 32 2 85 55–98 97 84–100 92 61–99 94 82–98 93 82–99
2 × clavicle 26 8 53 5 84 66–95 87 76–94 76 63–86 91 83–96 86 77–92
Sternum 14 3 26 3 82 57–96 90 73–98 82 61–93 90 75–96 87 74–95
2 × humerus 33 6 49 4 89 75–97 89 87–96 85 72–92 92 83–97 89 81–95
24 × ribs 339 19 718 28 92 89–95 97 96–98 95 92–97 96 95–97 96 94–99
7 × cervical vertebrae 76 17 210 19 80 71–88 93 88–96 82 74–88 92 88–94 89 85–92
12 × dorsal vertebrae 176 19 334 23 88 83–93 95 92–99 90 86–94 94 91–96 92 90–94
5 × lumbar vertebrae 70 16 133 11 86 77–93 89 83–94 81 73–88 92 87–95 88 83–92
Sacrum 15 4 25 2 88 64–99 86 68–96 79 60–91 93 77–98 87 74–95
2 × iliac bones 40 9 38 5 89 76–96 81 67–91 82 71–89 88 77–95 85 76–91
2 × pubic bones 12 1 71 8 60 36–81 99 93–100 92 62–99 90 84–94 90 82–95
2 × femurs 35 11 43 3 92 79–98 80 66–89 76 65–84 93 83–98 85 76–91
2 × tibias 20 3 66 3 87 66–97 96 88–99 87 69–95 96 88–98 93 86–98
Total skeletal metastases 867 117 1798 116 88 86–90 94 93–95 88 86–90 94 93–95 92 91–93
Organs Brain 7 2 35 2 78 40–97 95 82–99 78 47–93 95 84–98 91 79–98
Lung 14 3 21 8 64 41–83 88 68–97 82 61–93 72 60–82 76 61–87
Liver 16 0 30 0 100 97–100 100 88–100 100   100   100 92–100
Others 11 1 30 4 73 45–92 97 83–100 92 61–99 88 76–95 89 76–96
Total organ metastasis 48 6 116 14 77 65–87 95 90–98 89 78–95 89 84–93 89 84–93
Total   1069 202 2371 176 86 84–88 92 91–93 84 82–86 93 92–94 90 89–91
  1. Abbreviations: LN lymph node, TP true-positive, FP false-positive, TN true-negative, FN false-negative, CI confidence interval, NPV negative predictive value, PPV positive predictive value