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Table 3 Distribution of demographic, radiologic, and pathologic findings according to molecular classification

From: Role of ultrasound in predicting the molecular subtypes of invasive breast ductal carcinoma

 

TN (n = 26)

Luminal A (n = 82)

Luminal B (n = 26)

HER2 (n = 26)

P value1

P value2

P value3

No.

%

No.

%

No.

%

No.

%

Age (years)

       

 Mean ± SD

53.39 ± 9.58

53.49 ± 13.35

52.31 ± 11.34

49.85 ± 14.86

0.778

0.713

0.114

 Range

36.0–70.0

23.0–75.0

34.0–70.0

28.0–86.0

   

Size of lesion (cm)

       

 Mean ± SD

2.95 ± 1.68

3.18 ± 1.83

3.08 ± 1.51

3.02 ± 0.73

0.733

0.970

0.182

 Range

1.0–8.0

1.3–9.0

1.5–6.0

1.8–4.0

   

Echogenicity

           

 Isoechoic

6

23.1

14

17.1

4

15.4

6

23.1

0.564

0.482

1.000

 Hypoechoic/heterogeneous

20

76.9

68

82.9

22

84.6

20

76.9

   

Shape

           

 Oval or rounded

24

92.3

36

43.9

6

23.1

10

38.5

0.000*

0.000*

0.000*

 Irregular

2

7.7

46

56.1

20

76.9

16

61.5

   

Margin

           

 Angular or spiculated

2

7.7

61

74.4

16

61.5

12

46.2

0.000*

0.000*

0.002*

 Circumscribed or lobulated

24

92.3

21

25.6

10

38.5

14

53.8

   

Calcification

           

 Present

6

23.1

28

34.1

12

46.2

16

61.5

0.290

0.080

0.005*

 Absent

20

76.9

54

65.9

14

53.8

10

38.5

   

Orientation

           

 Parallel

10

38.5

12

14.6

2

7.7

6

23.1

0.009*

0.008*

0.229

 Non parallel

16

61.5

70

85.4

24

92.3

20

76.9

   

Boundary

           

 Abrupt interface

22

84.6

19

23.2

12

46.2

20

76.9

0.000*

0.004*

0.482

 Echogenic halo

4

15.4

63

76.8

14

53.8

6

23.1

   

Posterior feature

           

 Posterior shadowing

2

7.7

52

63.4

10

38.5

4

15.4

   

 Posterior enhancement or no posterior change

24

92.3

30

36.6

16

61.5

22

84.6

0.000*

0.008*

0.084

LN status

           

 Nodal metastasis

6

23.1

23

28.0

22

84.6

20

76.9

0.618

0.000*

0.000*

 No nodal metastasis

20

76.9

59

72.0

4

15.4

6

23.1

   

Multiplicity

           

 Unifocal

22

84.6

72

87.8

16

61.5

12

46.2

0.739

0.061

0.004*

 Multifocal or multicentric

4

15.4

10

12.2

10

38.5

14

53.8

   

Grade of IDC

           

 Low grade

4

15.4

76

92.7

22

84.6

8

30.8

0.000*

0.000*

0.188

 High grade

22

84.6

6

7.3

4

15.4

18

69.2

   
  1. *Result with statistically significant difference P < 0.05
  2. 1P value calculated the difference between TN and luminal A
  3. 2P value calculated the difference between TN and luminal B
  4. 3P value calculated the difference between TN and HER2