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Table 3 Distribution of demographic, radiologic, and pathologic findings according to molecular classification

From: Role of ultrasound in predicting the molecular subtypes of invasive breast ductal carcinoma

  TN (n = 26) Luminal A (n = 82) Luminal B (n = 26) HER2 (n = 26) P value1 P value2 P value3
No. % No. % No. % No. %
Age (years)        
 Mean ± SD 53.39 ± 9.58 53.49 ± 13.35 52.31 ± 11.34 49.85 ± 14.86 0.778 0.713 0.114
 Range 36.0–70.0 23.0–75.0 34.0–70.0 28.0–86.0    
Size of lesion (cm)        
 Mean ± SD 2.95 ± 1.68 3.18 ± 1.83 3.08 ± 1.51 3.02 ± 0.73 0.733 0.970 0.182
 Range 1.0–8.0 1.3–9.0 1.5–6.0 1.8–4.0    
Echogenicity            
 Isoechoic 6 23.1 14 17.1 4 15.4 6 23.1 0.564 0.482 1.000
 Hypoechoic/heterogeneous 20 76.9 68 82.9 22 84.6 20 76.9    
Shape            
 Oval or rounded 24 92.3 36 43.9 6 23.1 10 38.5 0.000* 0.000* 0.000*
 Irregular 2 7.7 46 56.1 20 76.9 16 61.5    
Margin            
 Angular or spiculated 2 7.7 61 74.4 16 61.5 12 46.2 0.000* 0.000* 0.002*
 Circumscribed or lobulated 24 92.3 21 25.6 10 38.5 14 53.8    
Calcification            
 Present 6 23.1 28 34.1 12 46.2 16 61.5 0.290 0.080 0.005*
 Absent 20 76.9 54 65.9 14 53.8 10 38.5    
Orientation            
 Parallel 10 38.5 12 14.6 2 7.7 6 23.1 0.009* 0.008* 0.229
 Non parallel 16 61.5 70 85.4 24 92.3 20 76.9    
Boundary            
 Abrupt interface 22 84.6 19 23.2 12 46.2 20 76.9 0.000* 0.004* 0.482
 Echogenic halo 4 15.4 63 76.8 14 53.8 6 23.1    
Posterior feature            
 Posterior shadowing 2 7.7 52 63.4 10 38.5 4 15.4    
 Posterior enhancement or no posterior change 24 92.3 30 36.6 16 61.5 22 84.6 0.000* 0.008* 0.084
LN status            
 Nodal metastasis 6 23.1 23 28.0 22 84.6 20 76.9 0.618 0.000* 0.000*
 No nodal metastasis 20 76.9 59 72.0 4 15.4 6 23.1    
Multiplicity            
 Unifocal 22 84.6 72 87.8 16 61.5 12 46.2 0.739 0.061 0.004*
 Multifocal or multicentric 4 15.4 10 12.2 10 38.5 14 53.8    
Grade of IDC            
 Low grade 4 15.4 76 92.7 22 84.6 8 30.8 0.000* 0.000* 0.188
 High grade 22 84.6 6 7.3 4 15.4 18 69.2    
  1. *Result with statistically significant difference P < 0.05
  2. 1P value calculated the difference between TN and luminal A
  3. 2P value calculated the difference between TN and luminal B
  4. 3P value calculated the difference between TN and HER2