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Table 4 Univariate and multivariate logistic regression analysis

From: Role of ultrasound in predicting the molecular subtypes of invasive breast ductal carcinoma

Subtype Univariate logistic regression analysis Multivariate logistic regression analysis
Predictive SS OR (95% C.I.) P value Independent predictors OR (95% C.I.) P value
Luminal A subtype Echogenic halo 7.46 (3.69–15.07) < 0.001* Echogenic halo 3.56 (1.46–8.69) 0.005*
Posterior shadowing 6.72 (3.30–13.66) < 0.001* Posterior shadowing 4.60 (1.78–11.89) 0.002*
Angular or spiculated margin 4.65 (2.37–9.12) < 0.001* Angular or spiculated margin 1.65 (0.66–4.16) 0.287
No nodal metastasis 4.10 (2.11–7.97) < 0.001* No nodal metastasis 5.40 (2.24–14.02) < 0.001*
Unifocal mass 4.03 (1.80–9.04) < 0.001* Unifocal mass 2.36 (0.91–6.08) 0.076
Luminal B subtype Nodal metastasis 9.54 (3.11–29.30) < 0.001* Nodal metastasis 2.54 (0.91–7.09) 0.075
Irregular shape 3.65 (1.38–9.65) 0.006* Irregular shape 8.04 (2.58–25.07) < 0.001*
HER2 subtype Nodal metastasis 5.43 (2.04–14.41) < 0.001* Nodal metastasis 4.17 (1.42–12.29) 0.010*
Unifocal mass 5.35 (2.20–13.00) < 0.001* Unifocal mass 2.90 (1.04–8.14) 0.043*
Abrupt interface 5.09 (1.92–13.52) < 0.001* Abrupt interface 2.73 (0.87–8.53) 0.084
Posterior enhancement or no posterior change 5.03 (1.64–15.38) 0.002* Posterior enhancement or no posterior change 3.45 (0.95–12.55) 0.060
Calcification 3.06 (1.29–7.28) 0.009* Calcification 2.76 (1.02–7.46) 0.045*
TN subtype Circumscribed or lobulated margin 23.73 (5.37–104.93) < 0.001* Circumscribed or lobulated margin 8.21 (1.41–47.83) 0.019*
Oval or rounded shape 18.92 (4.29–83.44) < 0.001* Oval or rounded shape 6.90 (1.29–36.83) 0.024*
Posterior enhancement or no posterior change 11.65 (2.65–51.25) < 0.001* Posterior enhancement or no posterior change 3.67 (0.60–22.51) 0.160
Abrupt interface 8.95 (2.92–27.46) < 0.001* Abrupt interface 1.38 (0.28–6.68) 0.691
Parallel orientation 3.56(1.42–8.96) 0.005* Parallel orientation 2.01 (0.61–6.59) 0.251
No nodal metastasis 3.14 (1.19–8.31) 0.017* No nodal metastasis 2.09 (0.62–7.03) 0.233
  1. Predictive SS sonographic signs
  2. *Result with statistically significant difference P < 0.05