From: Role of ultrasound in predicting the molecular subtypes of invasive breast ductal carcinoma
Subtype | Univariate logistic regression analysis | Multivariate logistic regression analysis | ||||
---|---|---|---|---|---|---|
Predictive SS | OR (95% C.I.) | P value | Independent predictors | OR (95% C.I.) | P value | |
Luminal A subtype | Echogenic halo | 7.46 (3.69–15.07) | < 0.001* | Echogenic halo | 3.56 (1.46–8.69) | 0.005* |
Posterior shadowing | 6.72 (3.30–13.66) | < 0.001* | Posterior shadowing | 4.60 (1.78–11.89) | 0.002* | |
Angular or spiculated margin | 4.65 (2.37–9.12) | < 0.001* | Angular or spiculated margin | 1.65 (0.66–4.16) | 0.287 | |
No nodal metastasis | 4.10 (2.11–7.97) | < 0.001* | No nodal metastasis | 5.40 (2.24–14.02) | < 0.001* | |
Unifocal mass | 4.03 (1.80–9.04) | < 0.001* | Unifocal mass | 2.36 (0.91–6.08) | 0.076 | |
Luminal B subtype | Nodal metastasis | 9.54 (3.11–29.30) | < 0.001* | Nodal metastasis | 2.54 (0.91–7.09) | 0.075 |
Irregular shape | 3.65 (1.38–9.65) | 0.006* | Irregular shape | 8.04 (2.58–25.07) | < 0.001* | |
HER2 subtype | Nodal metastasis | 5.43 (2.04–14.41) | < 0.001* | Nodal metastasis | 4.17 (1.42–12.29) | 0.010* |
Unifocal mass | 5.35 (2.20–13.00) | < 0.001* | Unifocal mass | 2.90 (1.04–8.14) | 0.043* | |
Abrupt interface | 5.09 (1.92–13.52) | < 0.001* | Abrupt interface | 2.73 (0.87–8.53) | 0.084 | |
Posterior enhancement or no posterior change | 5.03 (1.64–15.38) | 0.002* | Posterior enhancement or no posterior change | 3.45 (0.95–12.55) | 0.060 | |
Calcification | 3.06 (1.29–7.28) | 0.009* | Calcification | 2.76 (1.02–7.46) | 0.045* | |
TN subtype | Circumscribed or lobulated margin | 23.73 (5.37–104.93) | < 0.001* | Circumscribed or lobulated margin | 8.21 (1.41–47.83) | 0.019* |
Oval or rounded shape | 18.92 (4.29–83.44) | < 0.001* | Oval or rounded shape | 6.90 (1.29–36.83) | 0.024* | |
Posterior enhancement or no posterior change | 11.65 (2.65–51.25) | < 0.001* | Posterior enhancement or no posterior change | 3.67 (0.60–22.51) | 0.160 | |
Abrupt interface | 8.95 (2.92–27.46) | < 0.001* | Abrupt interface | 1.38 (0.28–6.68) | 0.691 | |
Parallel orientation | 3.56(1.42–8.96) | 0.005* | Parallel orientation | 2.01 (0.61–6.59) | 0.251 | |
No nodal metastasis | 3.14 (1.19–8.31) | 0.017* | No nodal metastasis | 2.09 (0.62–7.03) | 0.233 |