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Table 3 Diagnostic performance of qualitative (visual) data of ASL-MRI of both cerebral hemispheres (n = 52) of the studied patients (n = 26)

From: Arterial spin-labelling and magnetic resonance spectroscopy as imaging biomarkers for detection of epileptogenic zone in non-lesional focal impaired awareness epilepsy

Inter-ictal visual qualitative analysis PASL-MRI results Region of abnormal perfusion Total
Temporal Extra-temporal
No % No % No %
Non-localization and non-lateralization 1 3.85% 0 0% 1 3.85%
Well-localized and well-lateralized (21; 80.77%) Isolated ipsilateral focal hypoperfusion 14 53.84% 4 15.38% 18 69.22%
Isolated ipsilateral focal hyperperfusion 1 3.85% 1 3.85% 2 7.68%
Ipsilateral hypoperfusion (epileptogenic focus) with hypopefusion of the ipsilateral thalamus 0 0% 1 7.68% 1 3.85%
False-localization (2; 7.68%) Ipsilateral focal hypoperfusion of multiple cerebral lobes of the epileptogenic hemisphere including the epileptogenic irritative zone and associated ipsilateral cerebral areas of seizure spread, and focal hypopefusion of the ipsilateral thalamus 1 3.85% 0 0% 1 3.85%
Ipsilateral focal hypoperfusion of multiple cerebral lobes of the epileptogenic hemisphere including the epileptogenic irritative zone and associated ipsilateral cerebral areas of seizure spread 1 3.85% 0 0% 1 3.85%
False-lateralization (2; 7.68%) Ipsilateral hypoperfusion (epileptogenic focus) with hypopefusion of the contra-lateral lobes and/or contra-lateral thalamus 1 3.85% 0 0% 1 3.85%
Ipsilateral focal hypoperfusion (epileptogenic focus) with focal hypoperfusion of the corresponding contralateral homologous (mirror focus) 0 0% 1 3.85% 1 3.85%
Total 19 73.08% 7 26.92% 26 100%
Sensitivity, specificity, PPV, NPV and accuracy of visual analysis of PASL-MRI results in the inter-ictal state
Sensitivity % Specificity % PPV % NPV % Accuracy %
90.48 87.10% 82.61% 93.10% 88.46%
  1. PASL-MRI pulsed arterial spin labelled MRI, PPV positive predictive value, NPV negative predictive value.