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Table 5 The mean metabolite concentration ratios in brains of the studied patients (n = 26)

From: Arterial spin-labelling and magnetic resonance spectroscopy as imaging biomarkers for detection of epileptogenic zone in non-lesional focal impaired awareness epilepsy

Metabolite ratio in different brain regions

Ipsilateral side of the epileptogenic zone

Contralateral side

t

P value

Suggested zone of focal epileptogenic activity and its mirrored non-epileptic contralateral region

NAA/Cho

0.94 ± 0.08

1.21 ± 0.18

5.341

< 0.02*

NAA/Cr

0.86 ± 0.11

1.28 ± 0.14

1.181

0.01*

NAA/(Cho+Cr)

0.54 ± 0.62

0.93 ± 0.07

21.540

< 0.001*

MI/NAA

1.03 ± 0.21

0.72 ± 0.10

2.068

0.044*

Glx/NAA

1.56 ± 1.25

1.23 ± 1.12

18.451

< 0.001*

Glx/Cr

1.44 ± 0.24

1.21 ± 0.44

3.441

< 0.018*

Cerebral areas of seizure spread

NAA/Cho

1.23 ± 0.18

1.25 ± 0.18

2.344

0.163

NAA/Cr

1.27 ± 0.14

1.29 ± 0.14

3.235

0.132

NAA/(Cho+Cr)

0.84 ± 0.14

0.87 ± 0.15

5.416

0.072

MI/NAA

0.50 ± 0.01

0.69 ± 0.19

2.178

< 0.01*

Glx/NAA

1.28 ± 15

1.26 ± 14

1.246

0.120

Glx/Cr

1.23 ± 0.26

1.22 ± 0.26

1.521

0.641

Thalamus

NAA/Cho

1.19 ± 0.05

1.22 ± 0.06

35.254

< 0.11

NAA/Cr

1.23 ± 0.11

1.26 ± 0.12

24.351

< 0.43

NAA/(Cho+Cr)

0.60 ± 0.12

0.92 ± 0.13

-4.73

< 0.001*

MI/NAA

0.67 ± 0.13

0.72 ± 0.03

26.081

0.03*

Glx/NAA

1.49 ± 20

1.27 ± 19

1.246

< 0.02*

Glx/Cr

1.40 ± 0.32

1.37 ± 0.31

1.521

0.064

Basal ganglia

NAA/Cho

1.24 ± 0.07

1.26 ± 0.08

1.870

0.910

NAA/Cr

1.27 ± 0.10

1.25 ± 0.11

0.371

0.865

NAA/(Cho+Cr)

0.84 ± 0.12

0.87 ± 0.13

0.521

0.160

MI/NAA

0.81 ± 0.01

0.79 ± 0.02

0.462

0.754

Glx/NAA

1.25 ± 24

1.23 ± 23

0.162

0.110

Glx/Cr

1.25 ± 0.39

1.23 ± 0.37

1.253

0.064

Cerebellar hemispheres

NAA/Cho

1.27 ± 0.11

1.23 ± 0.10

1.355

0.183

NAA/Cr

1.28 ± 0.17

1.25 ± 0.16

1.095

0.279

NAA/ (Cho+Cr)

0.86 ± 0.16

0.82 ± 0.15

0.731

0.468

MI/NAA

0.76 ± 0.12

0.77 ± 0.11

1.651

0.124

Glx/NAA

1.27 ± 20

1.29 ± 20

0.162

0.210

Glx/Cr

1.23 ± 0.40

1.26 ± 0.39

1.253

0.064

  1. MV 1H-MRS multi-voxel proton magnetic resonance spectroscopy, ppm parts per million, NAA N-acetylaspartate, Cr creatine, Cho choline, Glx glutamate-glutamine, MI Myo-inositol, t t test, * significant if P value < 0.05