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Table 5 The mean metabolite concentration ratios in brains of the studied patients (n = 26)

From: Arterial spin-labelling and magnetic resonance spectroscopy as imaging biomarkers for detection of epileptogenic zone in non-lesional focal impaired awareness epilepsy

Metabolite ratio in different brain regions Ipsilateral side of the epileptogenic zone Contralateral side t P value
Suggested zone of focal epileptogenic activity and its mirrored non-epileptic contralateral region NAA/Cho 0.94 ± 0.08 1.21 ± 0.18 5.341 < 0.02*
NAA/Cr 0.86 ± 0.11 1.28 ± 0.14 1.181 0.01*
NAA/(Cho+Cr) 0.54 ± 0.62 0.93 ± 0.07 21.540 < 0.001*
MI/NAA 1.03 ± 0.21 0.72 ± 0.10 2.068 0.044*
Glx/NAA 1.56 ± 1.25 1.23 ± 1.12 18.451 < 0.001*
Glx/Cr 1.44 ± 0.24 1.21 ± 0.44 3.441 < 0.018*
Cerebral areas of seizure spread NAA/Cho 1.23 ± 0.18 1.25 ± 0.18 2.344 0.163
NAA/Cr 1.27 ± 0.14 1.29 ± 0.14 3.235 0.132
NAA/(Cho+Cr) 0.84 ± 0.14 0.87 ± 0.15 5.416 0.072
MI/NAA 0.50 ± 0.01 0.69 ± 0.19 2.178 < 0.01*
Glx/NAA 1.28 ± 15 1.26 ± 14 1.246 0.120
Glx/Cr 1.23 ± 0.26 1.22 ± 0.26 1.521 0.641
Thalamus NAA/Cho 1.19 ± 0.05 1.22 ± 0.06 35.254 < 0.11
NAA/Cr 1.23 ± 0.11 1.26 ± 0.12 24.351 < 0.43
NAA/(Cho+Cr) 0.60 ± 0.12 0.92 ± 0.13 -4.73 < 0.001*
MI/NAA 0.67 ± 0.13 0.72 ± 0.03 26.081 0.03*
Glx/NAA 1.49 ± 20 1.27 ± 19 1.246 < 0.02*
Glx/Cr 1.40 ± 0.32 1.37 ± 0.31 1.521 0.064
Basal ganglia NAA/Cho 1.24 ± 0.07 1.26 ± 0.08 1.870 0.910
NAA/Cr 1.27 ± 0.10 1.25 ± 0.11 0.371 0.865
NAA/(Cho+Cr) 0.84 ± 0.12 0.87 ± 0.13 0.521 0.160
MI/NAA 0.81 ± 0.01 0.79 ± 0.02 0.462 0.754
Glx/NAA 1.25 ± 24 1.23 ± 23 0.162 0.110
Glx/Cr 1.25 ± 0.39 1.23 ± 0.37 1.253 0.064
Cerebellar hemispheres NAA/Cho 1.27 ± 0.11 1.23 ± 0.10 1.355 0.183
NAA/Cr 1.28 ± 0.17 1.25 ± 0.16 1.095 0.279
NAA/ (Cho+Cr) 0.86 ± 0.16 0.82 ± 0.15 0.731 0.468
MI/NAA 0.76 ± 0.12 0.77 ± 0.11 1.651 0.124
Glx/NAA 1.27 ± 20 1.29 ± 20 0.162 0.210
Glx/Cr 1.23 ± 0.40 1.26 ± 0.39 1.253 0.064
  1. MV 1H-MRS multi-voxel proton magnetic resonance spectroscopy, ppm parts per million, NAA N-acetylaspartate, Cr creatine, Cho choline, Glx glutamate-glutamine, MI Myo-inositol, t t test, * significant if P value < 0.05