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Table 1 AJCC stage AJCC staging system

From: Gall bladder carcinoma: the facts and the mimics

AJCC stage Stage group Description
0 Tis Lesion is only in the epithelium and has not grown into deeper layers of the gall bladder (Tis)
  N0  
  M0 It has not spread to nearby lymph nodes (N0) or to distant sites (M0)
I T1 The tumor has grown into the lamina propria or the muscle layer (muscularis) (T1)
  N0  
  M0 It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
IIA T2a Lesion extends through the muscle layer into the fibrous tissue on the side of the peritoneum (T2a).
  N0  
  M0 It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
IIB T2b The lesion extends through the muscle layer into the fibrous tissue on the side of the liver, no invasion of the liver (T2b).
  N0  
  M0 It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
IIIA T1–3 The lesion has grown through the serosa and/or it has grown directly into the liver and/or one nearby structure like the stomach, duodenum, colon, pancreas (T3).
  N0  
  M0 It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
IVA T4 The tumor has grown into portal vein or hepatic artery or it has grown into 2 or more structures outside of the liver (T4). It may or may not have spread to no more than 3 nearby lymph nodes (N0 or N1).
  N0 or N1  
  M0 No distant spread.
IVB Any T The primary tumor may or may not have infiltrated out of the gall bladder. Spread to 4 or more regional lymph nodes (N2).
  N2  
  M0  
   OR
  Any T It has spread to distant sites such as the liver, peritoneum, or the lungs (M1).
  Any N  
  M1