Fig. 5
From: The role of diffusion-weighted MRI in assessment of response to chemotherapy in osteosarcoma
A 18-year-old male with osteosarcoma in the right humerus. MR images a–c before and d–f after chemotherapy. a, b Axial T2-WI and contrast-enhanced T1-WI showing cortically based meta-diaphyseal mass lesion circumferentially surrounding the right humerus infiltrating its medulla all over the shaft. It elicits heterogeneous high signal in T2 with heterogeneous contrast uptake. c ADC map showed diffusion restriction with mean ADC values of the most restricted ROIs about (mean, 1.29 × 10−3 mm2/s). d, e Follow-up conventional axial T2 and post contrast showing size progression and more contrast enhancement. f Follow-up ADC mapping showed no significant interval changes (1.3 × 10−3 mm2/s) indicating poor response