Fig. 4
A 29-year-old male patient with RRMS, EDSS score of 2, and a relapse rate of 2, complaining of sensory and pyramidal dysfunction. Axial and sagittal Flair sequences (a–c) showed multiple plaques of high SI seen at both parietal lobes; in periventricular white matter, pericallosal areas and centeum semiovale. The periventricular plaques are perpendicular to the ventricle giving Dawson’s finger appearance. 3D T1WI in sagittal view (d, e) for brain stem segmentation and in coronal view (f, g) for cerebellar white and grey matter segmentation; (d, f) raw unprocessed T1W image, (e, g) 3D T1 image after processing with 3D Slicer with colored segmented brain stem and cerebellum. The brain stem and cerebellar segmentation results showed the following data: midbrain 5.82 (N 5.24–6.33 cm3), pons 12.83 (N 12.66–16.51 cm3), medulla 3.87 (N 4.25–5.12 cm3), whole brain stem 22.52 (N 22.46–28.10 cm3), left cerebellar white matter 23.47 (N 19.06–25.21 cm3), left cerebellar grey matter 83.94 (N 84.39–102.17 cm3), right cerebellar white matter 22.82 (N 18.55–25.54 cm3), and right cerebellar grey matter 83.16 (N 84.36–101.87 cm3). Patient with EDSS score of 2 and a relapse rate of 2 had a moderate decrease in the volumes of the medulla and cerebellar grey matter bilaterally