Fig. 4

a Gross image showing a superficial ulcero-proliferative growth in sigmoid (red arrow). b, c Haematoxylin and eosin (H&E) lower magnification (× 40) images showing a tumour mainly arranged in glandular pattern. d, e H&E (× 100) demonstrating an adenocarcinoma infiltrating in to the underlying lamina propria. f H&E (× 400) shows individual glands having hyperchromatic nuclei with loss of nuclear stratification with intraluminal “dirty” necrosis, along with interspersed area showing mild acute and chronic inflammatory cell infiltrate