Skip to main content

Table 2 Distribution of patients according to clinical severity and HRCT characteristics with estimation of proportionate severity factor

From: COVID-19 clinico-radiological mismatch: a proposal for a novel combined morphologic/volumetric CT severity score with blinded validation

Clinical severity (respiratory status): Group (1) mild Group (2) border line severity Group (3) severe–critical Estimation of “total
severity factor" and approximated score points
-
-
-
O2 saturation and requirements:
Dyspnea:
Respiratory rate (RR):
95–100%,
Absent or mild (type I)
RR < 30/min
93–94% (+) one of:
High grade (type II or III)
RR ≥ 30/min
< 93% (O2 support or ventilation)
High grade (type II or III)
RR ≥ 30/min
- Total number (TN) and percentage (379) 298 (79%) 57 (15%) 24 (6%)
HRCT characteristics: N % a Severity
ratio
N % Severity
ratio
N % Severity
ratio
Total Points
Volumetric analysis:
[S1] 0–15% of lung volume is involved: Total: 271 (72%) 271 100% a 1.3 Negative Negative 1.3 1
[S2] 15–25% of lung volume is involved: Total: 51 (13%) 27 53% 0.7 24 47% 3.1 Negative 3.8 4
[S3] 25–50% of lung volume is involved: Total: 49 (13%) Negative 33 67% 4.5 16 33% 5.5 10 10
[S4] > 50% of lung volume is involved: Total: 8 (2%) Negative Negative 8 100% 16.7 16.7 17
Morphologic pattern:
[M1] Pure GGO: Total: 154 (41%) 150 97% 1.2 4 3% 0.2 Negative 1.4 1
[M2] GGOs with “Atoll sign”: Total: 50 (13%) 46 92% 1.2 4 8% 0.5 Negative 1.7 2
[M3] GGOs mixed with consolidations: Total: 80 (21%) 70 87% 1.1 10 13% 0.9 Negative 2 2
[M4] Homogeneous consolidations or “curvilinear” consolidations: Total: 29 (8%) 15 52% 0.7 14 48% 3.2 Negative 3.9 4
[M5] GGOs with “air bubble sign”: Total: 7 (2%) 3 43% 0.5 3 43% 2.9 1 14% 2.3 5.8 6
[M6] GGOs with early secondary fibrosis and architectural distortion: Total: 26 (7%) 7 27% 0.3 11 42% 2.8 8 31% 5.2 8.3 8
[M7] Patchy GGOs with smooth septal thickening “focal crazy-paving” pattern: Total: 26 (7%) 7 27% 0.3 11 42% 2.8 8 31% 5.2 8.3 8
              Maximum (SF = 25)
[M8] It refers to diffuse alveolar damage pattern (DAD);
- By definition, it is diffused (> 50%) of lung volume involvement [S4]
- By definition, it represents mixed GGOs with “crazy-paving pattern” and “air bubble sign.”
  Total: 7 (2%) Negative Negative 7 (100%)  
  1. a Severity ratio = prevalence rate of HRCT finding among the total number of each patients’ group/prevalence rate of each patients’ group among total sample size; example 100%/79% = 1.3