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Table 4 Comparison of diagnostic performance for transition zone prostate cancer detection between PI-RADS v2.1 and PI-RADS v2.1-B

From: In prostatic transition zone lesions (PI-RADS v2.1): which subgroup should be biopsied?

  Reader 1 Reader 2
PI-RADS P value PI-RADS P value
v 2.1 v 2.1-B v 2.1 v 2.1-B
Sensitivity 100 (91/91) 97.8 (89/91) 0.155 100 (91/91) 96.7 (88/91) 0.081
Specificity 38.1 (24/63) 93.7 (59/63) < 0.000 17.0 (8/47) 90.5 (57/63) < 0.000
Positive predictive value 70.0 (91/130) 95.7 (89/93) < 0.000 70.0 (91/130) 93.6 (88/94) < 0.000
Negative predictive value 100 (24/24) 96.7 (59/61) 0.369 100 (8/8) 95.0 (57/60) 0.518
AUC 0.933 (0.896-0.971) 0.972 (0.946-0.998)   0.926 (0.896–0.965) 0.960 (0.929–0.991)  
  1. AUC area under the receiver operating characteristic curve