Breast involvement of hematological malignancies: imaging and clinical findings

Durhan, Gamze; Demirkazık, Figen

doi:10.1186/s43055-021-00558-2

Egyptian Journal of Radiology and Nuclear Medicine

Table 1 Clinical and radiological findings of 20 patients with breast involvement of hematological malignancies

From: Breast involvement of hematological malignancies: imaging and clinical findings

Case	Age	Pathologic type	Primary/secondary lymphoma	Size (mm)	Side^a	Axillary LAP/skin thickening	MMG	US	MRI
1	83	Diffuse large B-cell lymphoma	Primary	36	Left^a	+/+	NA	Irregular/non-circumscribed Hypoechoic Posterior enhancement Vascularity: NA	NA
2	57	Diffuse large B-cell lymphoma	Primary	11	Right	+/+	Oval-round Circumscribed Isodense	Oval-round/non-circumscribed Hypoechoic Posterior enhancement Hypervascularity	NA
3	37	Diffuse large B-cell lymphoma	Secondary	13	Bilateral	+/+	Asymmetric density Isodense	Irregular/non-circumscribed Hypoechoic Posterior phenomena: − Vascularity: NA	NA
4	47	Diffuse large B-cell lymphoma	Secondary	160	Left	+/+	NA	Irregular/non-circumscribed Heterogeneous Posterior phenomena: − Vascularity: NA	NA
5	57	Diffuse large B-cell lymphoma	Secondary	47	Right^a	+/−	Asymmetric density Hyperdense	Oval-round/non-circumscribed Heterogeneous ^c Posterior enhancement Vascularity: NA	Dynamic curve, 2 Diffusion restriction (ADC 0.542 × 10⁻³) T2-hyperintense
6	67	Diffuse large B-cell lymphoma	Primary	81	Right^a	−/+	NA	Oval-round/circumscribed Heterogeneous ^c Posterior enhancement Vascularity: NA	NA
7	65	Diffuse large B-cell lymphoma	Secondary	22	Bilateral	+/+	Oval-round Circumscribed Hyperdense	Oval-round/circumscribed Hypoechoic Posterior phenomena: − Hypervascularity	NA
8	62	Marginal zone lymphoma	Secondary	30	Left^a	−/−	Oval-round Circumscribed Isodense	Oval-round/circumscribed Heterogeneous ^c Posterior enhancement Hypervascularity	NA
9	69	Marginal zone lymphoma	Secondary	14	Bilateral	+/−	Oval-round Circumscribed Hyperdense	Oval-round/circumscribed Hypoechoic Posterior enhancement Hypervascularity	NA
10	77	Marginal zone lymphoma	Secondary	54	Left^a	+/−	NA	Irregular/non-circumscribed Heterogeneous Posterior enhancement Vascularity: NA	NA
11	48	Marginal zone lymphoma	Primary	13	Right^a	+/+	NA	Irregular/non-circumscribed Hypoechoic Posterior enhancement Hypervascularity	NA
12	55	Marginal zone lymphoma	Secondary	32	Left	+/−	Irregular Non-circumscribed Hyperdense	Irregular/non-circumscribed Hypoechoic Posterior enhancement Vascularity: NA	Dynamic curve, 2 Diffusion restriction (ADC 0.558 × 10⁻³) T2-hyperintense
13	19	Granulocytic sarcoma	Primary	35	Left	−/−	NA	Oval-round/circumscribed Heterogeneous ^c Posterior enhancement Hypervascularity	NA
14	50	Granulocytic sarcoma	Secondary	25	Left	−/+	NA	Irregular/non-circumscribed Heterogeneous ^c Posterior enhancement Vascularity: NA	NA
15^d	22	Granulocytic sarcoma	Secondary	47	Bilateral	+/+ ^b	Oval-round Circumscribed Hyperdense	Oval-round Circumscribed Heterogeneous ^c Posterior enhancement Vascularity: NA	Dynamiccurve, 3 Diffusion restriction (ADC 0.403 × 10⁻³) T2-hyperintense
16	21	Hodgkin lymphoma	Secondary	40	Bilateral	+/+	NA	Irregular/non-circumscribed Heterogeneous ^c Posterior phenomena: − Vascularity: NA	NA
17	36	Hodgkin lymphoma	Secondary	60	Right	−/+	Irregular Non-circumscribed Hyperdense	Irregular/non-circumscribed Heterogeneous Posterior enhancement Hypervascularity	NA
18	22	Precursor B lymphoblastic lymphoma	Secondary	42	Right^a	−/−	NA	Irregular/non-circumscribed Heterogeneous Posterior enhancement Hypervascularity	NA
19	36	Mycosis fungoides	Secondary	46	Right^a	+/+^b	NA	Irregular/non-circumscribed Heterogeneous Posterior phenomena: − Hypervascularity	NA
20	58	Plasmacytoma	Secondary	9	Right^a	+/−	Oval-round Circumscribed Hyperdense	Oval-round/Circumscribed Hypoechoic Vertical orientation Posterior phenomena: − Hypervascularity	Dynamic curve, 2 Diffusion restriction (ADC 0.840 × 10⁻³) T2-hyperintense

Abbreviations: LAP lymphadenopathy, US ultrasonography, MMG mammography, MRI magnetic resonance imaging, NA not applicable, ADC apparent diffusion coefficient
^aShows single lesions within the left or right breast
^bSkin thickening is because of invasion by the mass
^cHeterogeneity is due to hyperechoic areas
^dThis patient has multiple lesions, some of which have an oval-round shape, circumscribed margins, and type 3 dynamic curve, while others show irregular shape, not-circumscribed margin, and type 2 dynamic curve

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