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Table 5 Diagnostic performance of the studied ratios for the outcome of patients by ROC curve analysis

From: Magnetic resonance imaging and spectroscopy in evaluation of hypoxic ischemic encephalopathy in pediatric age group

  Cutoff Sensitivity %
(95% CI)
Specificity %
(95% CI)
AUC 95% CI of AUC P value
Lac/Cr ratio in BG > 0.38 95 (75.1–99.9) 90.1 (55.5–99.7) 0.93 0.74–0.98 < 0.001*
Lac/Cr ratio in thalamus > 0.36 80 (56.3–94.3) 100 (69.2–100) 0.94 0.78–0.99 < 0.001*
Lac/Cr ratio in frontal WM > 0.42 85 (62.1–96.8 80 (44.4–97.5) 0.91 0.77–0.99 < 0.001*
Lac/Cr ratio occipital > 0.42 87 (62.5–97) 100 (69.2–100) 0.93 0.76–0.99 < 0.001*
NAA/Cr ratio in BG ≤ 0.9 90 (68.3–98.8) 90 (55.5–99.7) 0.91 0.75–0.98 < 0.001*
NAA/Cr ratio in thalamus ≤ 0.75 80 (56.5–94.5) 92 (95.5–99.7) 0.93 0.78–0.99 < 0.001*
NAA/Cr ratio in frontal WM ≤ 0.9 95 (75.1–99.9) 70 (34.8–93.3) 0.90 0.74-.98 < 0.001*
NAA/Cr ratio in occipital WM ≤ 0.8 90 (68.3–98.8) 80 (44.4–97.5) 0.82 0.64–0.93 < 0.001*
NAA/Cho ratio in BG ≤ 0.29 95 (75.3–99.5) 87 (44.4–99.5) 0.78 0.59–0.91 < 0.001*
NAA/Cho ratio in thalamus ≤ 0.25 80 (56.3–94.3) 89 (45.5–99.9) 0.86 0.69–0.96 < 0.001*
NAA/Cho ratio in frontal WM ≤ 0.31 95 (75.1–99.9) 80 (44.4–97.5) 0.80 0.61–0.92 < 0.001*
NAA/Cho ratio in occipital WM ≤ 0.30 95 (75.1–99.9) 75 (54.4–98.5) 0.79 0.59–0.91 < 0.001*
  1. *Significant at p < 0.05