Table 5 Diagnostic performance of the studied ratios for the outcome of patients by ROC curve analysis
Cutoff | Sensitivity % (95% CI) | Specificity % (95% CI) | AUC | 95% CI of AUC | P value | |
|---|---|---|---|---|---|---|
Lac/Cr ratio in BG | > 0.38 | 95 (75.1–99.9) | 90.1 (55.5–99.7) | 0.93 | 0.74–0.98 | < 0.001* |
Lac/Cr ratio in thalamus | > 0.36 | 80 (56.3–94.3) | 100 (69.2–100) | 0.94 | 0.78–0.99 | < 0.001* |
Lac/Cr ratio in frontal WM | > 0.42 | 85 (62.1–96.8 | 80 (44.4–97.5) | 0.91 | 0.77–0.99 | < 0.001* |
Lac/Cr ratio occipital | > 0.42 | 87 (62.5–97) | 100 (69.2–100) | 0.93 | 0.76–0.99 | < 0.001* |
NAA/Cr ratio in BG | ≤ 0.9 | 90 (68.3–98.8) | 90 (55.5–99.7) | 0.91 | 0.75–0.98 | < 0.001* |
NAA/Cr ratio in thalamus | ≤ 0.75 | 80 (56.5–94.5) | 92 (95.5–99.7) | 0.93 | 0.78–0.99 | < 0.001* |
NAA/Cr ratio in frontal WM | ≤ 0.9 | 95 (75.1–99.9) | 70 (34.8–93.3) | 0.90 | 0.74-.98 | < 0.001* |
NAA/Cr ratio in occipital WM | ≤ 0.8 | 90 (68.3–98.8) | 80 (44.4–97.5) | 0.82 | 0.64–0.93 | < 0.001* |
NAA/Cho ratio in BG | ≤ 0.29 | 95 (75.3–99.5) | 87 (44.4–99.5) | 0.78 | 0.59–0.91 | < 0.001* |
NAA/Cho ratio in thalamus | ≤ 0.25 | 80 (56.3–94.3) | 89 (45.5–99.9) | 0.86 | 0.69–0.96 | < 0.001* |
NAA/Cho ratio in frontal WM | ≤ 0.31 | 95 (75.1–99.9) | 80 (44.4–97.5) | 0.80 | 0.61–0.92 | < 0.001* |
NAA/Cho ratio in occipital WM | ≤ 0.30 | 95 (75.1–99.9) | 75 (54.4–98.5) | 0.79 | 0.59–0.91 | < 0.001* |