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Table 2 Diagnostic accuracy of magnetic resonance imaging (MRI) parameters to predict hepatic steatosis with the best predictive cutoffs

From: Quantitative MDCT and MRI assessment of hepatic steatosis in genotype 4 chronic hepatitis C patients with fibrosis

 

AUC (95% CI)

SE

SP

PPV

NPV

 + LR

− LR

p

For the prediction of liver steatosis

T1-fat fraction > -13.7%

0.808 (0.637–0.922)

66.7

90

94

53.5

6.7

0.4

< 0.001

Fat percentage (> 5.1%)

0.702 (0521–0.846)

54.2

80

86.4

42.7

2.7

0.6

0.030

Proton density fat fraction (> 4.95%)

0.958 (0.828–0.995)

95.8

90

95.7

90.1

9.6

0.1

< 0.001

For the prediction of mild liver steatosis

T1-fat fraction > −13.7%

0.845 (0.622–0.963)

72.7

90

74.4

89.2

7.3

0.3

< 0.001

Fat percentage (> 5.1%)

0.650 (0.414–0.841)

45.5

80

47.7

78.6

2.3

0.7

0.217

Proton density fat fraction (> 4.95%)

0.910 (0.701–0.987)

91

90

78.5

96.1

9.1

0.1

< 0.001

For the prediction of moderate liver steatosis

T1-fat fraction (> 0.4%)

0.654 (0.466–0.812)

27.3

100

100

77.4

0.7

0.147

Fat percentage (> 2.8%)

0.652 (0.463–0.810)

90.9

38.1

37

91.3

1.5

0.2

0.154

Proton density fat fraction (> 8.44%)

0.931 (0.782–0.988)

100

85.7

73.7

100

7

0

< 0.001

For the prediction of severe liver steatosis

T1-fat fraction (> 6.2%)

0.619 (0.445–0.773)

40

100

100

91.8

0.6

0.942

Fat percentage (> 6.1%)

0.850 (0.694–0.945)

100

65.6

30.3

100

2.9

0

0.0742

Proton density fat fraction (> 20.4%)

0.975 (0.861–995)

100

93.8

70.7

100

16

0

< 0.001

  1. AUC area under the receiver operating characteristic curve, + LR positive likelihood ratio, − LR negative likelihood ratio, NPV negative predictive value, PPV positive predictive value, SP specificity, SE sensitivity