Use of diffusion-weighted imaging and diffusion tensor imaging in assessment of myometrial invasion in patients of endometrial carcinoma and its correlation with histopathological grading (Prospective study)

Egyptian Journal of Radiology and Nuclear Medicine

Table 6 Validity of FA, ADC and MD in differentiating endometrial carcinoma grades

	AUC (95% CI)	P value	Cutoff point	Sensitivity %	Specificity%	PPV%	NPV%	Accuracy%
Grade 3 from grade 1 or 2 endometrioid adenocarcinoma
DT-FA	0.942 (0.860–1.0)	< 0.001*	0.236	90.9	96.4	90.9	96.4	94.9
DT-MD	0.894 (0.793–0.99)	< 0.001*	0.825	81.8	82.1	64.3	92.0	84.6
DW-ADC	0.894 (0.793–0.996)	< 0.001*	0.916	90.9	64.3	50.0	94.7	74.4
Grade 2 or 3 from grade 1 endometrioid adenocarcinoma
DT-FA	0.980 (0.947–1.0)	< 0.001*	0.335	94.4	85.7	85.0	94.7	90.0
DT-MD	0.918 (0.81–1.0)	< 0.001*	0.983	88.9	90.5	88.9	90.5	89.7
DW-ADC	0.884 (0.774–0.99)	< 0.001*	0.941	77.8	85.7	82.4	81.8	84.6

*Highly significant
AUC area under curve, CI confidence interval, NPV negative predictive value, PPV positive predictive value