Risk stratification of endometrial cancer and lymph node metastases prediction using 18F-FDG PET/CT: role of metabolic tumor volume and total lesion glycolysis

Egyptian Journal of Radiology and Nuclear Medicine

Table 3 Sensitivity and Specificity of different PET-CT parameters for LNMs detection and risk stratification of EC

	AUC	P value	95% CI	Cut-off value	Sensitivity (%)	Specificity (%)
Histopathological grade
SUV_max	0.711	0.0246	0.528 to 0.855	> 14.65	72.22	73.33
SUV_mean	0.663	0.0963	0.478 to 0.817	> 7.12	77.78	53.33
MTV	0.796	0.0003	0.620 to 0.916	> 25.596	77.78	80
TLG	0.759	0.0025	0.579 to 0.890	> 192.653	77.78	66.67
Myometrial invasion
SUV_max	0.911	< 0.0001	0.759 to 0.982	> 14.55	88.89	86.67
SUV_mean	0.852	< 0.0001	0.685 to 0.951	> 7.15	88.89	73.33
MTV	0.837	< 0.0001	0.667 to 0.942	> 25.596	77.78	80
TLG	0.911	< 0.0001	0.759 to 0.982	> 192.653	88.89	80
LVSI
SUV_max	0.848	< 0.0001	0.681 to 0.949	> 14.65	86.67	77.78
SUV_mean	0.804	0.0002	0.629 to 0.921	> 9.15	66.67	88.89
MTV	0.848	< 0.0001	0.681 to 0.949	> 25.596	86.67	77.78
TLG	0.889	< 0.0001	0.731 to 0.971	> 179.374	100	66.67
LNMs
SUV_max	0.856	< 0.0001	0.691 to 0.954	> 18.34	77.78	87.50
SUV_mean	0.861	< 0.0001	0.696 to 0.956	> 7.54	100	62.50
MTV	0.852	< 0.0001	0.685 to 0.951	> 30.125	88.89	79.17
TLG	0.921	< 0.0001	0.773 to 0.986	> 249.366	88.89	83.33
Risk stratification
SUV_max	0.839	< 0.0001	0.670 to 0.943	> 14.55	77.27	90.91
SUV_mean	0.785	0.0007	0.608 to 0.908	> 7.12	81.82	72.73
MTV	0.826	< 0.0001	0.655 to 0.935	> 25.596	72.73	90.91
TLG	0.839	< 0.0001	0.670 to 0.943	> 192.653	77.27	81.82

AUC, Area Under the Curve, LVSI, Lymph-vascular space invasion, LNMs, Lymph nodes metastases