Twenty-eight-week gestation; prenatal ultrasound revealed absent septum pellucidum; and mono-ventricle and unilateral cleft palate. SSFSE T2WIs axial and coronal planes at the level of lateral ventricle a, b revealed absent septum pellucidum with partially cleaved anterior cerebrum and abnormal configuration of lateral ventricles that appears as mono-ventricle with partially developed occipital and temporal horns, but deficient frontal horns and incomplete falx cerebri. Incompletely formed interhemispheric fissure, especially anteriorly. Attempts of 3rd ventricle formation with partially fused thalami. Smooth surface of the brain with minimal attempts of sulcation. Sagittal plane (c) showed the most posterior portion of corpus callosum is seen with deficient anterior part. Sagittal and axial planes c, and d revealed midline facial anomalies in the form of hypotelorism [IOD = 12 mm (< 5% percentile), (N for GA = 17.7 mm)] and unilateral cleft lip (arrow). MRI diagnosis: Semi-lobar holoprosencephaly associated with lissencephaly and facial anomalies in the form of hypotelorism and cleft lip. Recommendation: Termination of pregnancy.