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Table 2 Findings regarding the response prediction pre and post-therapy based on the IVIM factors value and tumor size

From: Assessment of intravoxel incoherent motion MR imaging for differential diagnosis of breast lesions and evaluation of response: a systematic review

Author Year IVIM mean (× 10−3 mm2/s) or % change Tumor size P value
Pre-NAC Post-NAC Before NAC (cm) After NAC (cm) %Change
Response or Baseline Nonresponse Response Nonresponse
D D* F D D* F D D* F D D* f
Suo et al. [35] 2021 1.00 ± 0.83 15.62 ± 4.18 9.27 ± 3.66 0.98 ± 0.80 15.44 ± 3.70 9.27 ± 2.98 0.78 ± 0.68  − 3.06 ± 6.36 1.78 ± 4.33 0.25 ± 0.35  − 1.97 ± 6.35 0.82 ± 3.86 39.8 ± 21.2 NA  − 34.0 ± 18.9 0.009
Kim et al. [36] 2018 1.22 5.87 45.17 1.10 7.33 43.33 1.37↑ 6.04↑ 49.56↑ 1.15↑ 6.58↓ 45.23↑ 4.15 (2.2–9.3) 3.05 (1.1–7.8)  − 20.22 (− 54.9–4.4) 0.023
Cho et al. [37] 2017 1.02 25.05 8.8 NA NA NA 0.99↓ 25.54↑ 8.7↓ 1.05↑ 17.16↓ 11.7↑ 13.84 (3.43, 44.45) 13.80 (3.43, 37.00)  − 40.2% 0.452
Che et al. [38] 2016 0.92 10.10 32.40 0.83 9.40 24.40 1.36 ± 0.30↑ 8.98↓ 14.51 ± 7.25↓ 0.98 ± 0.23↑ 20.00↑ 20.69 ± 5.10↓ 4.89–1.52 2.57 (2.03, 4.16)  − 39.2%  < 0.001
Bedair et al. [39] 2017 0.85 ± 0.05 NA 12.10 ± 2.02 1.02 ± 0.05 NA 10.32 ± 1.15 1.30 ± 0.14 (↑36%) NA 8.48 ± 1.54 (↓29%) 1.28 ± 0.15 (↑23%) NA 10.53 ± 2.51 (↑5%) 1.2–12 4.1 ± 0.4 1.5 ± 0.2 0.14