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Table 2 Findings regarding the response prediction pre and post-therapy based on the IVIM factors value and tumor size

From: Assessment of intravoxel incoherent motion MR imaging for differential diagnosis of breast lesions and evaluation of response: a systematic review

Author

Year

IVIM mean (× 10−3 mm2/s) or % change

Tumor size

P value

Pre-NAC

Post-NAC

Before NAC (cm)

After NAC (cm)

%Change

Response or Baseline

Nonresponse

Response

Nonresponse

D

D*

F

D

D*

F

D

D*

F

D

D*

f

Suo et al. [35]

2021

1.00 ± 0.83

15.62 ± 4.18

9.27 ± 3.66

0.98 ± 0.80

15.44 ± 3.70

9.27 ± 2.98

0.78 ± 0.68

 − 3.06 ± 6.36

1.78 ± 4.33

0.25 ± 0.35

 − 1.97 ± 6.35

0.82 ± 3.86

39.8 ± 21.2

NA

 − 34.0 ± 18.9

0.009

Kim et al. [36]

2018

1.22

5.87

45.17

1.10

7.33

43.33

1.37↑

6.04↑

49.56↑

1.15↑

6.58↓

45.23↑

4.15 (2.2–9.3)

3.05 (1.1–7.8)

 − 20.22 (− 54.9–4.4)

0.023

Cho et al. [37]

2017

1.02

25.05

8.8

NA

NA

NA

0.99↓

25.54↑

8.7↓

1.05↑

17.16↓

11.7↑

13.84 (3.43, 44.45)

13.80 (3.43, 37.00)

 − 40.2%

0.452

Che et al. [38]

2016

0.92

10.10

32.40

0.83

9.40

24.40

1.36 ± 0.30↑

8.98↓

14.51 ± 7.25↓

0.98 ± 0.23↑

20.00↑

20.69 ± 5.10↓

4.89–1.52

2.57 (2.03, 4.16)

 − 39.2%

 < 0.001

Bedair et al. [39]

2017

0.85 ± 0.05

NA

12.10 ± 2.02

1.02 ± 0.05

NA

10.32 ± 1.15

1.30 ± 0.14 (↑36%)

NA

8.48 ± 1.54 (↓29%)

1.28 ± 0.15 (↑23%)

NA

10.53 ± 2.51 (↑5%)

1.2–12

4.1 ± 0.4

1.5 ± 0.2

0.14