Table 1 Distribution of patients according to thymus CT-grades of involution, patients' age, blood lymphocytic count, CT-severity score, and clinical course during COVID-19 infection
Sub-involuted thymus (42/325 = 12.9%) | Thymus fatty involution (283/325 = 87.1%) | |||
|---|---|---|---|---|
Grade 0 (solid) | Grade 1 [solid (> 50%) and fat) | Grade 2 [solid and fat (> 50%)] = Reticulonodular pattern) | Grade 3 (complete fatty replacement) | |
Total number | 6/325 | 7/325 | 29/325 | 283/325 |
Age | ||||
20–40 years | 6 (100%) (P = 0.024)** | 7 (100%) (P = 0.014)** | 21 (72.4%) (P = 0.042)** | 143 (50.5%) |
41–60 years | 0 (P = 0.071) | 0 (P = 0.055) | 8 (27.6) (P = 0.395) | 105 (37.1%) |
61–80 years | 0 (P = 0.390) | 0 (P = 0.353) | 0 (P = 0.05) | 35 (12.4%) |
Lymphocytes | ||||
Lymphopenia | 0 (P = 0.0001)** | 0 (P = 0.00004)** | 13 (44.8%) (P = 0.005)** | 208 (73.5%) |
Normal or lymphocytosis | 6 (100%) (P = 0.0001)** | 7 (100%) (P = 0.00004)** | 16 (45.2%) (P = 0.005)** | 75 (26.5%) |
Lung CT-score | ||||
0% (Clear lung) | 4 (66.7%) (P ≤ 0.0001)** | 4 (57.1%) (P ≤ 0.0001)** | 7 (24.1%) (P ≤ 0.0001)** | 0 |
1–25% | 2 (33.3) (P = 0.04) | 3 (42.9%) (P = 0.096) | 22 (75.9%) (P = 0.551) | 204 (72.1%) |
25–50% | 0 (P = 0.259) | 0 (P = 0.222) | 0 (P = 0.01)** | 56 (19.8%) |
51–75% | 0 (P = 0.574) | 0 (P = 0.505) | 0 (P = 0.157) | 19 (6.7%) |
76–100% | 0 (P = 0.783) | 0 (P = 0.765) | 0 (P = 0.529) | 4 (1.4%) |
Symptoms | ||||
Mild | 6 (100%) (P = 0.235) | 7 (100%) (P = 0.199) | 29 (100%) (P = 0.007)** | 222 (78.4%) |
Severe | 0 (P = 0.235) | 0 (P = 0.199) | 0 (P = 0.007)** | 61 (21.6%) |