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Table 3 FDG uptake versus PYP uptake in the muscles of seven IIM patients. (a) SUVmean and (b) SUVmax

From: Treatment-naïve idiopathic inflammatory myopathy: disease evaluation by fluorodeoxyglucose versus pyrophosphate

  FDG uptake PYP uptake Difference FDG–PYP
95% CI
p value Ratio FDG/PYP
95% CI
p value
(a)       
Upper limb       
 M. deltoideus dx 1.11 ± 0.30 0.38 ± 0.14 0.73 ± 0.19
(0.56–0.90)
< 0.0001 2.91 ± 0.48
(2.47–3.35)
< 0.0001
 M. biceps dx 1.35 ± 0.41 0.37 ± 0.17 0.98 ± 0.31
(0.69–1.27)
0.0002 3.65 ± 1.17
(2.56–4.74)
0.001
 M. triceps dx 0.91 ± 0.22 0.31 ± 0.12 0.60 ± 0.18
(0.43–0.77)
0.0001 2.93 ± 0.91
(2.09–3.77)
0.001
Lower limb       
 M. gluteus maximus dx 0.77 ± 0.12 0.33 ± 0.03 0.44 ± 0.11
(0.33–0.54)
< 0.0001 2.31 ± 0.32
(2.02–2.60)
< 0.0001
 M. quadriceps femoris dx 0.84 ± 0.08 0.31 ± 0.03 0.53 ± 0.07
(0.47–0.60)
< 0.0001 2.74 ± 0.18
(2.57–2.91)
< 0.0001
Derived variable       
 Volume-weighted average SUVmean for all upper limb muscles 1.10 ± 0.17 0.36 ± 0.11 0.74 ± 0.13
(0.62–0.87)
< 0.0001 3.07 ± 0.76
(2.37–3.77)
0.0004
 Volume-weighted average SUVmean for all lower limb muscles 0.80 ± 0.07 0.32 ± 0.02 0.48 ± 0.07
(0.42–0.54)
< 0.0001 2.49 ± 0.23
(2.28–2.71)
< 0.0001
 Volume-weighted average SUVmean for all muscles 0.87 ± 0.08 0.33 ± 0.03 0.54 ± 0.07
(0.47–0.60)
< 0.0001 2.62 ± 0.26
(2.38–2.85)
< 0.0001
(b)       
Upper limb       
 M. deltoideus dx 2.42 ± 0.57 0.93 ± 0.30 1.49 ± 0.45
(1.08–1.90)
0.0001 2.60 ± 0.65
(2.01–3.20)
0.0006
 M. biceps dx 3.94 ± 3.20 1.04 ± 0.50 2.90 ± 2.76
(0.34–5.45)
0.03 3.79 ± 1.66
(2.26–5.32)
0.004
 M. triceps dx 1.92 ± 0.51 0.78 ± 0.21 1.13 ± 0.45
(0.72–1.55)
0.0005 2.45 ± 0.68
(1.82–3.08)
0.001
Lower limb       
 M. gluteus maximus dx 2.78 ± 2.26 1.17 ± 0.26 1.61 ± 2.04
(− 0.28–3.50)
0.08 2.38 ± 1.52
(0.97–3.78)
0.05
 M. quadriceps femoris dx 2.34 ± 0.72 1.03 ± 0.30 1.31 ± 0.59
(0.76–1.85)
0.001 2.26 ± 0.60
(1.71–2.81)
0.001
Derived variable       
 Volume-weighted average SUVmax for all upper limb muscles 2.51 ± 0.68 0.91 ± 0.24 1.60 ± 0.61
(1.04–2.17)
0.0005 2.76 ± 0.79
(2.03–3.49)
0.001
 Volume-weighted average SUVmax for all lower limb muscles 2.59 ± 1.58 1.12 ± 0.21 1.47 ± 1.43
(0.15–2.80)
0.03 2.31 ± 1.13
(1.27–3.36)
0.02
 Volume-weighted average SUVmax for all muscles 2.57 ± 1.34 1.07 ± 0.20 1.50 ± 1.24
(0.35–2.64)
0.02 2.40 ± 1.05
(1.43–3.37)
0.01
  1. SUV Standardized uptake value (g/ml)