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Table 1 Diagnostic performance of the T1 and T2 Dixon modalities

From: Dixon chemical shift MR sequences for demonstrating of bone marrow vertebral metastasis

Measure T2 Dixon (WO) T2 Dixon (OP) T1 post-contrast Dixon (WO) T1 and T2 Dixon (FO) T1 post-contrast Dixon (OP)
True positive 126 126 149 144 133
True negative 21 21 21 21 21
False positive 0 0 0 0 0
False negative 35 35 12 17 27
Sensitivity 78.3% (71.1%–84.4%) 78.3% (71.1%–84.4%) 92.6% (87.3%–96.1%) 89.4% (83.6%–93.7%) 83.1% (76.4%–88.6%)
Specificity 100% (83.9%–100%) 100% (83.9%–100%) 100% (83.9%–100%) 100% (83.9%–100%) 100% (83.9%–100%)
PPV 100% 100% 100% 100% 100%
NPV 37.5% (30.9%–44.6%) 37.5% (30.9%–44.6%) 63.6% (50.4%–75.1%) 55.3% (44.1%–65.9%) 43.8% (35.5%–52.3%)
LR- 21.7% (16.2%–29.1%) 21.7% (16.2%–29.1%) 7.5% (4.3%–12.8%) 10.6% (6.7%–16.6%) 16.9% (12%–23.8%)
Accuracy 80.8% (74.3%–86.2%) 80.8% (74.3%–86.2%) 93.4% (88.8%–96.5%) 90.7% (85.5%–94.5%) 85.1% (79%–89.9%)
F1 score 87.8% 87.8% 96.1% 94.4% 90.8%
MCC 54.2% 54.2% 76.7% 70.3% 60.3%
AUC 0.891 (0.837–0.933) 0.891 (0.837–0.933) 0.963 (0.924–0.985) 0.947 (0.904–0.975) 0.916 (0.865–0.952)
  1. 95% confidence intervals are presented between brackets
  2. All measures were calculated by Confusion Matrix Online Calculator (https://onlineconfusionmatrix.com, accessed December 2, 2021) [18] and MedCalc Software Ltd. Diagnostic test evaluation calculator, Version 20.018 (https://www.medcalc.org/calc/diagnostic_test.php, accessed December 2, 2021) [19]
  3. PPV positive predictive value; NPV negative predictive value; LR- negative likelihood ratio; MCC Matthews correlation coefficient; AUC area under the curve