Egyptian Journal of Radiology and Nuclear Medicine

Table 6 Relation between the molecular markers and the MRI features (n = 80)

From: Magnetic resonance imaging correlation with molecular and epigenetic markers in assessment of breast cancer

	Molecular markers										Test of Sig	p
	Luminal A (n = 37)		Luminal B HER2-negative (n = 19)		Luminal B HER2-positive (n = 12)		HER2-amplified (n = 4)		Triple-negative (n = 8)
	No	%	No	%	No	%	No	%	No	%
Non-mass	(n = 3)		(n = 5)		(n = 6)		(n = 2)		(n = 1)
Distribution
Focal	0	0.0	2	40.0	0	0.0	0	0.0	0	0.0	χ² = 12.502	^MCp = 0.438
Linear	0	0.0	1	20.0	1	16.7	1	50.0	0	0.0
Segmental	3	100.0	2	40.0	4	66.7	0	0.0	1	100.0
Regional	0	0.0	0	0.0	1	16.7	1	50.0	0	0.0
Patterns
Homogenous	0	0.0	2	40.0	0	0.0	0	0.0	0	0.0	χ² = 11.883	^MCp = 0.055
Clumped	3	100.0	3	60.0	6	100.0	2	100.0	0	0.0
Clustered ring	0	0.0	0	0.0	0	0.0	0	0.0	1	100.0
T2 signal
Low-intermediate	36	97.3	19	100.0	12	100.0	4	100.0	6	75.0	χ² = 6.558	^MCp = 0.086
High signal	1	2.7	0	0.0	0	0.0	0	0.0	2	25.0	χ² = 6.558	^MCp = 0.086
Kinetic curve
Plateau	14	37.8	6	31.6	6	50.0	2	50.0	2	25.0	χ² = 2.014	^MCp = 0.760
Washout	23	62.2	13	68.4	6	50.0	2	50.0	6	75.0	χ² = 2.014	^MCp = 0.760
Lymph nodes
No	10	27.0	2	10.5	2	16.7	1	25.0	1	12.5	χ² = 2.590	^MCp = 0.641
Yes	27	73.0	17	89.5	10	83.3	3	75.0	7	87.5	χ² = 2.590	^MCp = 0.641
ADC value
Min.–Max	0.88–1.10		0.88–0.98		0.88–1.04		0.98–1.02		0.96–1.03		F = 10.242*	< 0.001*
Mean ± SD	0.98 ± 0.04		0.92 ± 0.03		0.94 ± 0.04		1.0 ± 0 .02		0.99 ± 0.02
Median	0.98		0.92		0.94		1.0		0.99
Associated features
No	22	59.5	4	21.1	3	25.0	0	0.0	3	37.5	χ² = 11.832*	^MCp = 0.013*
Yes	15	40.5	15	78.9	9	75.0	4	100.0	5	62.5	χ² = 11.832*	^MCp = 0.013*
Skin thickening	8	53.3	8	53.3	2	22.2	2	50.0	4	80.0	χ² = 4.617	^MCp = 0.321
Nipple retraction	4	26.7	1	6.7	2	22.2	0	0.0	0	0.0	χ² = 3.450	^MCp = 0.485
Perilesional edema	5	33.3	9	60.0	9	100.0	3	75.0	2	40.0	χ² = 12.037*	^MCp = 0.009*
Pectoral muscle invasion	1	6.7	1	6.7	1	11.1	1	25.0	0	0.0	χ² = 2.556	^MCp = 0.745

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