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Table 7 The molecular markers statistically significant correlations with MRI features

From: Magnetic resonance imaging correlation with molecular and epigenetic markers in assessment of breast cancer

 

Molecular markers

Test of Sig

p

Luminal A (n = 37)

Luminal B HER2-negative (n = 19)

Luminal B HER2-positive (n = 12)

HER2-amplified (n = 4)

Triple-negative (n = 8)

No

%

No

%

No

%

No

%

No

%

MRI lesion type

Mass

34

91.9

14

73.7

6

50.0

2

50.0

7

87.5

χ2 = 14.826*

MCp = 0.021*

Non-mass

2

5.4

2

10.5

4

33.3

1

25.0

0

0.0

Mass + Non-mass

1

2.7

3

15.8

2

16.7

1

25.0

1

12.5

Mass

(n = 35)

(n = 17)

(n = 8)

(n = 3)

    

Size (cm)

 < 2

14

40.0

0

0.0

1

12.5

0

0.0

0

0.0

χ2 = 14.044*

MCp = 0.003*

 ≥ 2

21

60.0

17

100.0

7

87.5

3

100.0

8

100.0

Shape

Regular

1

2.9

1

5.9

1

12.5

2

66.7

2

25.0

χ2 = 11.166*

MCp = 0.009*

Irregular

34

97.1

16

94.1

7

87.5

1

33.3

6

75.0

Patterns

Homogenous

7

20.0

1

5.9

2

25.0

0

0.0

0

0.0

χ2 = 23.638*

MCp  < 0.001*

Heterogeneous

27

77.1

15

88.2

5

62.5

0

0.0

4

50.0

Rim enhancement

1

2.9

1

5.9

1

12.5

3

100.0

4

50.0

ADC value

Min.–Max

0.88–1.10

0.88–0.98

0.88–1.04

0.98–1.02

0.96–1.03

F = 10.242*

 < 0.001*

Mean ± SD

0.98 ± 0.04

0.92 ± 0.03

0.94 ± 0.04

1.0 ± 0 .02

0.99 ± 0.02

Median

0.98

0.92

0.94

1.0

0.99

Associated features

Perilesional edema

5

33.3

9

60.0

9

100.0

3

75.0

2

40.0

χ2 = 12.037*

MCp = 0.009*