Fig. 2

A 18F-florbetaben PET transaxial images of healthy control (HC), patients with Parkinson's disease (PD), dementia with Lewy bodies (DLB), mild cognitive impairment (MCI), Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and vascular dementia (VaD). AD patients show cortical 18F-florbetaben uptake and non-specific white matter uptake visible in negative scans of HC, PD, FTLD, and VaD. All images are scaled to the same SUVR maximum. This research was initially published in JNM. Villemagne et al. B, 2011 [58]. B She has a family history of dementia in her sister's late 60s. Difficulty completing the MMSE. She had been diagnosed with MS, and MRI imaging had been consistent with demyelination Brain MRI showed several inflammatory demyelinating lesions. API was positive. Axial T2-weighted C Coronal FLAIR images through the brain showing typical MS lesions in the periventricular white matter perpendicular to the ependymal surface. Note generalized neuroparenchyma loss, with relative sparing of the temporal lobe white matter (left mesial temporal atrophy score is 2; correct mesial temporal atrophy score is 1). D Sagittal and coronal amyloid PET images demonstrating generalized increased activity within the cortical gray matter in all lobes with complete loss of gray-white differentiation consistent with widespread amyloid deposition. This research was initially published in J. Neurol. M Kolanko et al. 2020 [30]