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Table 2 Comparative analytic performance of quantitative MRI parameters

From: Suspicious lung lesions for malignancy: the lesion-to-spinal cord signal intensity ratio in T2WI and DWI–MRI versus PET/CT; a prospective pathologic correlated study with accuracy and ROC analyses

P-value

AUC

Cutoff

Sensitivity

Specificity

PPV

NPV

T2WI based L-to-SC SI ratio

 < 0.001*

0.860

> 1#

96.4%

80.0%

90%

92.3%

b500-DWI based L-to-SC SI ratio

 < 0.001*

0.863

> 0.7#

71.4%

86.7%

90.9%

61.9%

Mean ADC value in 10−3mm2/s

 < 0.01*

0.77

≤ 1.2#

71.4%

83.3%

84%

70.5%

Minimum ADC value in 10−3mm2/s

 < 0.001*

0.77

≤ 0.9#

85.7%

66.7%

75.9%

79.2%

  1. L-to-SC SI ratio Lesion-to-spinal cord signal intensity ratio
  2. AUC area under curve, NPV negative predictive value, PPV positive predictive value
  3. *Statistically significant at p ≤ 0.05
  4. #Cutoff value was estimated by Mann–Whitney U and Student-T tests and chosen according to Youden index