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Table 1 Summary of results in group (B) and (C) including ILD characterization, % of patients involved, radiological signs, and further investigatory tools

From: Viral hepatitis and interstitial lung diseases: can HRCT assess their relation and characterize its pattern?

ILD Predominant pattern in visual score Final diagnosis Group [B]: high viremia Group [C]: high viremia, restrictive PFT
    No % Radiological signs Confirming investigation No % Radiological signs Confirming investigation
Fibrotic ILD Reticular pattern Interstitial pneumonia (IP) UIP Absent 17 PF and “honey combing” No need
Fibrosing NSIP 19 PF and traction bronchiectasis/bronchiolectasis BAL (↑neutrophils, eosinophils and lymphocytes)
Non-IP (mimic) Chronic HP 10 PF or septal thickening with “head cheese” BAL (↑mast cells and lymphocytes with macrophages)
Sarcoidosis (stage II:IV) 4 Peri-bronchial fibro-nodular changes Bronchoscopy, thoracoscopy, and biopsy
Non-fibrotic ILD Attenuation and nodular pattern Interstitial pneumonia (IP) Cellular NSIP 10 Sub-pleural GG No need Absent
COP 3 Peri-bronchial “Atol sign” BAL (↑ lymphocytes 20–40% and
↓ CD4/CD8 ratio is 0.3-0.5)
CEP 2 Sub-pleural “Atol sign” BAL (↑eosinophils 40–80% and ↑
CD4/CD8 ratio)
LIP 1 GG and cysts BAL (↑lymphocytes)
Non-IP (mimic) Sub-acute HP 8 Diffuse centrilobular GG nodules and “head cheese” Clinical diagnosis
Alveolar proteinosis 1 “Crazy paving” BAL (↑ protein SP-A and SP-D and Ig-G)
Sarcoidosis (stage I) 2 Bilateral hilar and nodal enlargement Bronchoscopy and biopsy
Total 27% (mild relation) 50% (moderate relation)