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Table 2 Comparison of tumor volume and ADC measurements between local control and local failure patient groups

From: Diffusion-weighted magnetic resonance imaging (DWMRI) of head and neck squamous cell carcinoma: could it be an imaging biomarker for prediction of response to chemoradiation therapy

  Local control Local failure P
Before treatment (total = 46) (n = 22) (n = 24)  
Mean ADC (ADCpre) (× 10−3 mm2/s)    
Min.–Max. 0.7–1.2 0.76–1.4 0.001*
Mean ± SD 0.89 ± 0.1 1.1 ± 0.2
Median (IQR) 0.87(0.8–1) 1(0.98 – 1.2)
ADC skewness    
Min.–Max. − 0.55–1.6 − 0.69–0.96 0.442
Mean ± SD 0.53 ± 0.67 0.39 ± 0.45
Median (IQR) 0.53(0.04–1.1) 0.45(0.12–0.79)
ADC kurtosis    
Min.–Max. − 0.68–8.8 0.09–4.1 0.792
Mean ± SD 2.4 ± 2.9 1.4 ± 0.99
Median (IQR) 1.8(0.15–3.5) 1.3(0.74–2)
Tumor volume (TVpre) (cm3)    
Min.–Max. 0.5–127.5 1.6–120 0.097
Mean ± SD 27.3 ± 33.6 35.1 ± 26.4
Median (IQR) 11.3(4–35) 28.4(21.5–43.6)
Midtreatment (total = 29) (n = 15) (n = 14)  
ΔADC (%)    
Min.–Max. 13.9–118.8 − 3.5–66.3 0.008*
Mean ± SD 45.2 ± 27.8 21.8 ± 21.3
Median (IQR) 38.9(26.9–52.5) 14.1(9.7–34.1)
TVmid (cm3)    
Min.–Max. 0.68–65 3–117 0.007*
Mean ± SD 8.76 ± 14.4 25.5 ± 32.8
Median (IQR) 2.5(0.9–7.9) 14.9(3.6–30)
ΔTV (%)    
Min. – Max. 15.2–95.1 − 96.9–89.7 0.100
Mean ± SD. 61.6 ± 28 24 ± 62.3
Median (IQR) 72.8(32.3–80.9) 36.4(2.3–\79.3)
  1. P P value for comparing between the two groups using Mann–Whitney test
  2. *Statistically significant at P ≤ 0.05