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Table 2 Comparison of tumor volume and ADC measurements between local control and local failure patient groups

From: Diffusion-weighted magnetic resonance imaging (DWMRI) of head and neck squamous cell carcinoma: could it be an imaging biomarker for prediction of response to chemoradiation therapy

 

Local control

Local failure

P

Before treatment (total = 46)

(n = 22)

(n = 24)

 

Mean ADC (ADCpre) (× 10−3 mm2/s)

   

Min.–Max.

0.7–1.2

0.76–1.4

0.001*

Mean ± SD

0.89 ± 0.1

1.1 ± 0.2

Median (IQR)

0.87(0.8–1)

1(0.98 – 1.2)

ADC skewness

   

Min.–Max.

− 0.55–1.6

− 0.69–0.96

0.442

Mean ± SD

0.53 ± 0.67

0.39 ± 0.45

Median (IQR)

0.53(0.04–1.1)

0.45(0.12–0.79)

ADC kurtosis

   

Min.–Max.

− 0.68–8.8

0.09–4.1

0.792

Mean ± SD

2.4 ± 2.9

1.4 ± 0.99

Median (IQR)

1.8(0.15–3.5)

1.3(0.74–2)

Tumor volume (TVpre) (cm3)

   

Min.–Max.

0.5–127.5

1.6–120

0.097

Mean ± SD

27.3 ± 33.6

35.1 ± 26.4

Median (IQR)

11.3(4–35)

28.4(21.5–43.6)

Midtreatment (total = 29)

(n = 15)

(n = 14)

 

ΔADC (%)

   

Min.–Max.

13.9–118.8

− 3.5–66.3

0.008*

Mean ± SD

45.2 ± 27.8

21.8 ± 21.3

Median (IQR)

38.9(26.9–52.5)

14.1(9.7–34.1)

TVmid (cm3)

   

Min.–Max.

0.68–65

3–117

0.007*

Mean ± SD

8.76 ± 14.4

25.5 ± 32.8

Median (IQR)

2.5(0.9–7.9)

14.9(3.6–30)

ΔTV (%)

   

Min. – Max.

15.2–95.1

− 96.9–89.7

0.100

Mean ± SD.

61.6 ± 28

24 ± 62.3

Median (IQR)

72.8(32.3–80.9)

36.4(2.3–\79.3)

  1. P P value for comparing between the two groups using Mann–Whitney test
  2. *Statistically significant at P ≤ 0.05