Table 7 Cut-off values with sensitivity, specificity, predictive values and accuracy of PASL-MRI and 1H-MRS in identification of epileptogenic zone in patients with FIAE (n= 26)
Quantitative imaging parameters | Cut-off | AUC | Sensitivity % | Specificity % | PPV % | NPV % | Accuracy % | ||
|---|---|---|---|---|---|---|---|---|---|
PASL-MRI parameters | rCBF (ml/100 g/min) | ≤ 64.87 | 0.957 | 98.31 | 92.90 | 95.97 | 88.89 | 94.75 | |
ASLAI % | ≥ 5.96% | 0.968 | 96.01 | 91.70 | 89.68 | 95.82 | 95.78 | ||
MV 1H-MRS parameters | Metabolite concentration ratios (in ppm) | NAA/Cho | ≤ 0.78 | 0.949 | 93.0 | 91.7 | 90.8 | 92.7 | 93.94 |
NAA/Cr | ≤ 0.89 | 0.889 | 89.3 | 88.2 | 92.6 | 83.3 | 88.9 | ||
NAA/(Cho+Cr) | ≤ 0.59 | 0.977 | 100 | 96.9 | 96.7 | 100 | 97.74 | ||
MI/NAA | ≥ 0.98 | 0.989 | 100 | 96.34 | 95.38 | 100 | 97.86 | ||
Glx/NAA | ≥ 1.55 | 0.972 | 100 | 96.35 | 95.68 | 100 | 97.24 | ||
Glx/Cr | ≥ 1.39 | 0.955 | 92.06 | 90.24% | 93.88 | 93.67 | 94.53 | ||
%AF | ≥ 9.98% | 0.983 | 100 | 97.65 | 98.31 | 100 | 98.14 | ||
Combined use of ASL-MRI and MV 1H-MRS | 100 | 98.45 | 97.81 | 99.6 | 98.86 | ||||