Fig. 4
From: The role of diffusion-weighted MRI in assessment of response to chemotherapy in osteosarcoma
A 9-year-old female, diagnosed as parosteal osteosarcoma of left tibia. MR images a–f before and g–j after chemotherapy. a–d Coronal STIR, Axial T1, T2-WI and contrast-enhanced T1-WI showing cortically based diaphyseal mass lesion circumferentially involving the anterolateral and posterior surfaces of the left tibial mid shaft with thickening of the cortex. It elicits heterogeneous high signal in STIR, low signal in T1, high signal in T2, with heterogeneous contrast uptake. e, f DWI and ADC map showed diffusion restriction with mean ADC values about (mean, 1.08 × 10−3 mm2/s). g, h Follow-up axial T2 and axial post contrast showing marked regression in the size and enhancement of the mass. i, j Follow-up ADC mapping and ROI inserted over the most restricted areas revealed increase in the values (mean values of 2 × 10−3 mm2/s) denoting good therapeutic response