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Table 2 Histopathological scoring

From: Role of hepatobiliary scintigraphy with different semi-quantitative parameters along with histopathological scoring in differentiating biliary atresia from neonatal hepatitis

Scoring parameter Pathologic diagnosis P value
BA (21)
Number and %
NH (40)
Number and %
Portal duct proliferation: < 0.001*
▪ None (0) 1 (4.8%) 33 (82.5%)
▪ Mild (1) 2 (9.5%) 4 (10%)
▪ Moderate (2) 9 (42.9%) 3 (7.3%)
▪ Marked (3) 9 (42.9%) 0 (0.0%)
Bile plug in portal ductules < 0.001*
• Absent (0) 5 (23.8%) 34 (85%)
• Present (2) 16 (76.2%) 6 (15%)
Porto-portal bridging: < 0.001*
• None (0) 3 (14.3%) 34 (85%)
• < 50% of portal tracts (1) 9 (42.9%) 5 (12.5%)
• > 50% of portal tracts (2) 9 (42.9%) 1 (2.5%)
Lymphocytic infiltrate in portal region 0.048*
• None (2) 0 (0%) 0 (0%)
• Mild (1) 14 (66.7%) 16 (40%)
• Moderate/Sever (0) 7 (33.3%) 24 (60%)
Multinucleated hepatocyte 0.167*
• None (2) 9 (42.9%) 8 (20%)
• Only around central vein (1) 8 (38.1%) 21(52.5%)
• Diffuse (0) 4 (19%) 11 (27.5%)
Neutrophils in the infiltrate: 0.297*
• Absent or mild (1) 21(100%) 38 (95%)
• Moderate or marked (0) 0 (0.0 %) 2 (5%)
Hepatocellular swelling 0.176*
• None (2) 6 (28.6%) 4 (10%)
• Mild/focal (1) 11(52.4%) 26 (65%)
• Periportal / diffuse (0) 4 (19%) 10 (25%)
Total score < 0.01**
Mean ± SD 9.1 ± 2.5 3.8 ± 1.6
  1. Statistical relationships were evaluated by Chi-square test* and independent sample t-test**