Table 2 Histopathological scoring
Scoring parameter | Pathologic diagnosis | P value | |
|---|---|---|---|
BA (21) Number and % | NH (40) Number and % | ||
Portal duct proliferation: | < 0.001* | ||
▪ None (0) | 1 (4.8%) | 33 (82.5%) | |
▪ Mild (1) | 2 (9.5%) | 4 (10%) | |
▪ Moderate (2) | 9 (42.9%) | 3 (7.3%) | |
▪ Marked (3) | 9 (42.9%) | 0 (0.0%) | |
Bile plug in portal ductules | < 0.001* | ||
• Absent (0) | 5 (23.8%) | 34 (85%) | |
• Present (2) | 16 (76.2%) | 6 (15%) | |
Porto-portal bridging: | < 0.001* | ||
• None (0) | 3 (14.3%) | 34 (85%) | |
• < 50% of portal tracts (1) | 9 (42.9%) | 5 (12.5%) | |
• > 50% of portal tracts (2) | 9 (42.9%) | 1 (2.5%) | |
Lymphocytic infiltrate in portal region | 0.048* | ||
• None (2) | 0 (0%) | 0 (0%) | |
• Mild (1) | 14 (66.7%) | 16 (40%) | |
• Moderate/Sever (0) | 7 (33.3%) | 24 (60%) | |
Multinucleated hepatocyte | 0.167* | ||
• None (2) | 9 (42.9%) | 8 (20%) | |
• Only around central vein (1) | 8 (38.1%) | 21(52.5%) | |
• Diffuse (0) | 4 (19%) | 11 (27.5%) | |
Neutrophils in the infiltrate: | 0.297* | ||
• Absent or mild (1) | 21(100%) | 38 (95%) | |
• Moderate or marked (0) | 0 (0.0 %) | 2 (5%) | |
Hepatocellular swelling | 0.176* | ||
• None (2) | 6 (28.6%) | 4 (10%) | |
• Mild/focal (1) | 11(52.4%) | 26 (65%) | |
• Periportal / diffuse (0) | 4 (19%) | 10 (25%) | |
Total score | < 0.01** | ||
Mean ± SD | 9.1 ± 2.5 | 3.8 ± 1.6 | |