Quantitative analysis of white matter brain changes in tinnitus patients with normal hearing: a case-controlled study with diffusion tensor imaging

Eltabbakh, Amira; Nada, Nashwa

doi:10.1186/s43055-023-01024-x

Egyptian Journal of Radiology and Nuclear Medicine

Table 2 Comparison between study (Tinnitus) and control (normal hearing) group as regards fractional anisotropy (FA) measured at different brain sites

From: Quantitative analysis of white matter brain changes in tinnitus patients with normal hearing: a case-controlled study with diffusion tensor imaging

FA	Tinnitus group Mean ± SD	Control group Mean ± SD	Tinnitus group median (IQ range)	Control group median (IQ range)	p value	Parametric (t) test/nonparametric Mann–Whitney (U)
Rt LL	0.4086 ± 0.08883	0.4193 ± 0.1277	0.4100 (0.3125–0.4900)	0.4500 (0.2675–0.5225)	0.7986	t = 0.2578
Lt LL	0.3500 ± 0.1054	0.4757 ± 0.1578	0.3150 (0.2875–0.4050)	0.4950 (0.3350–0.5525)	0.0381	U = 53
Right IC	0.4243 ± 0.09036	0.5579 ± 0.2073	0.4500 (0.4000–0.4700)	0.6400 (0.4000–0.7325)	0.0213	U = 48.50
Left IC	0.4779 ± 0.08145	0.5157 ± 0.2239	0.4400 (0.4000–0.5600)	0.5450 (0.3475–0.7125)	0.5573	t = 0.5946
Right MGB	0.3614 ± 0.1104	0.3571 ± 0.1774	0.3400 (0.2800–0.4850)	0.3650 (0.2100–0.4025)	0.7946	U = 92
Left MGB	0.3729 ± 0.1086	0.4164 ± 0.1649	0.3550 (0.3100–0.4350)	0.3700 (0.3300–0.4625)	0.5032	U = 83
Right AC	0.2886 ± 0.06479	0.3571 ± 0.1467	0.3100 (0.2400–0.3300)	0.3550 (0.2625–0.4950)	0.1272	t = 1.600, df = 17.88
Left AC	0.2614 ± 0.1066	0.3250 ± 0.1746	0.2300 (0.1500–0.3800)	0.2950 (0.1775- 0.5425)	0.2554	t = 1.163, df = 26
Right AMG	0.1700 ± 0.02987	0.1757 ± 0.08178	0.1700 (0.1400–0.1900)	0.1550 (0.1100–0.2000)	0.4433	U = 81
Left AMG	0.1686 ± 0.02905	0.2593 ± 0.2717	0.1600 (0.1500–0.1800)	0.1650 (0.1175–0.2275)	0.8999	U = 93
Right hippocampus	0.3171 ± 0.1401	0.2750 ± 0.1360	0.3700 (0.1500–0.4000)	0.2500 (0.1550–0.3650)	0.4266	t = 0.8077, df = 26
Left hippocampus	0.3143 ± 0.1233	0.2929 ± 0.1459	0.3500 (0.1600–0.4300)	0.2500 (0.1575–0.4475)	0.6581	U = 88
Right para hippocampus	0.1500 ± 0.02418	0.2529 ± 0.2260	0.1500 (0.1300–0.1600)	0.2000 (0.1300–0.2675)	0.0986	U = 62
Left para hippocampus	0.1471 ± 0.03024	0.1786 ± 0.03570	0.1300 (0.1300–0.1900)	0.1850 (0.1450–0.2100)	0.0185	t = 2.513, df = 26
Right frontal AF	0.3243 ± 0.05515	0.4814 ± 0.1458	0.3300 (0.3000–0.3700)	0.4600 (0.3650–0.5400)	0.0016	t = 3.773, df = 16.65
Left frontal AF	0.3471 ± 0.09840	0.4786 ± 0.1303	0.3300 (0.2300–0.4300)	0.4450 (0.3825–0.5850)	0.0057	t = 3.012, df = 26
Right parietal AF	0.4186 ± 0.06163	0.4593 ± 0.1824	0.4400 (0.3700–0.4600)	0.4250 (0.3475–0.6025)	0.4360	t = 0.7911, df = 26
Left parietal AF	0.4100 ± 0.1129	0.4550 ± 0.1718	0.3800 (0.3100–0.4800)	0.4250 (0.3450–0.4700)	0.6263	U = 78
Splenium	0.7229 ± 0.2023	0.7686 ± 0.1558	0.8000 (0.7100–0.8500)	0.8100 (0.7200–0.8850)	0.2393	U = 72
Genu	0.6500 ± 0.2028	0.6400 ± 0.2200	0.6900 (0.6400–0.7900)	0.7300 (0.4925–0.8000)	0.6584	U = 88

Areas that showed significant levels of changes between two groups are expressed in bold
AC: auditory cortex, AF: arcuate fasciculus, AMG: amygdala, FA: fractional Anisotropy, IC: inferior colliculus, LL: lateral lemniscus, Lt: left, MGB: medial geniculate body, Rt: right

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