Fig. 2

This is a 47-year-old female presented with left breast erythema and peau d’orange of 6 months duration proved to be HER2 enriched subtype breast carcinoma. A Right breast deeply seated masses of partly obscured margins (arrows). Left breast global/diffuse asymmetry (circle), marked coarsened trabeculation, nipple retraction and diffuse dermal thickening seen on digital mammogram; note the left axillary enlarged nodes obvious at the mediolateral oblique view. B Breast ultrasound, the left image showed infiltrative solid mass of the left breast measured 11 cm in max. length and indeterminate ipsilateral axillary nodes, that showed asymmetrical uniform cortical thickening of 0.3 cm, yet with preserved central fatty hilum. C Subtraction post-contrast MR imaging showed the right breast masses with evident benign features of oval shape, circumscribed border, and homogenous contrast uptake (arrow). A full demonstration of the left breast disease was presented by a locally advanced breast carcinoma in the form of diffuse soft tissue infiltration (mass). Concomitant markedly thickened skin which is less enhancing than the breast carcinoma suggesting eczematous inflammatory changes rather than dermal infiltration as confirmed by mastectomy