Structural integrity of grey and white matter in schizophrenic patients by diffusion tensor imaging

Egyptian Journal of Radiology and Nuclear Medicine

Table 5 Performance of receiver operating characteristic ROC curves of mean diffusivity in different areas of white and grey matter to predict schizophrenic patients

	AUC	95% CI	p value	Cutoff	Sensitivity (%)	Specificity (%)
Fractional anisotropy
Fornix	0.924	0.920–0.956	< 0.001*	≤ 0.42	96.0	96.0
Corpus callosum	0.932	0.929–0.998	< 0.001*	≤ 0.5	96.0	96.0
Right cingulum	0.910	0.902–0.977	< 0.001*	≤ 0.41	92.0	92.0
Right superior occipito-frontal fasciculus	0.881	0.872–0.990	< 0.001*	≤ 0.39	92.0	90.0
Right inferior occipito-frontal fasciculus	0.970	0.929–0.988	< 0.001*	≤ 0.51	92.0	90.0
Right thalamus	0.574	0.426–0.712	0.384	≤ 0.3	72.0	76.0
Right basal ganglion	0.661	0.513–0.789	0.048*	≤ 0.27	60.0	48.0
Mean diffusivity × 10^–9 mm²/s
Fornix	0.521	0.375–0.664	0.807	≤ 4.7 × 10^–9	72.0	82.0
Corpus callosum	0.972	0.929–0.976	< 0.001*	> 4.6 × 10^–9	90.0	84.0
Right cingulum	0.521	0.375–0.664	0.805	> 2.86 × 10^–9	38.0	56.0
Right superior occipito-frontal fasciculus	0.562	0.415–0.702	0.450	> 2.8 × 10^–9	40.0	76.0
Right inferior occipito-frontal fasciculus	0.95	0.865–0.996	< 0.001*	> 1.7 × 10^–9	96.0	88.0
Right thalamus	0.926	0.815–0.981	< 0.001*	> 2.5 × 10^–9	96.0	72.0
Right basal ganglion	0.993	0.915–0.962	< 0.001*	> 2.5 × 10^–9	76.0	70.0

AUC area under the curve, CI confidence interval of AUC, p p value from a test comparing the AUC to the null hypothesis of AUC = 0.5, NPV negative predictive value, PPV positive predictive value
*Significant at p ≤ 0.05