A proposed inclusion of magnetic resonance imaging features to the VI RADS to enhance its accuracy in predicting muscle invasion

Egyptian Journal of Radiology and Nuclear Medicine

Table 3 Diagnostic performance for mean and minimum ADC values by ROI and volume methods to predict muscle invasion

ADC values	AUC	P	Cutoff ^#	Sensitivity	Specificity	PPV	NPV
Mean ADC for 3 ROIs	0.781	< 0.001*	≤ 0.76^#	76.92	75.61	75.0	77.5
Mean ADC for whole tumor volume	0.834	< 0.001*	≤ 0.88^#	92.31	63.41	70.6	89.7
Minimum ADC single ROI	0.857	< 0.001*	≤ 0.62^#	97.44	58.54	69.1	96.0
Minimum ADC for whole tumor volume	0.799	< 0.001*	≤ 0.37^#	84.62	65.85	70.2	81.8

AUC area under a curve, p value probability value, NPV negative predictive value, PPV positive predictive value, *Statistically significant at p ≤ 0.05 #: Cutoff for Youden index