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Egyptian Journal of Radiology and Nuclear Medicine

Table 2 Comparison of the diagnostic methods’ efficacies of the mass size groups and the entire cohort

From: Value of S-Detect combined with multimodal ultrasound in differentiating malignant from benign breast masses

Diagnostic method

Size

AUC

Accuracy, %

Sensitivity, %

Specificity, %

PPV, %

NPV, %

US

 ≤ 20 mm

0.856 (0.772–0.941)

85.7 (78.8–92.6)

75.0 (66.5–83.5)

90.1 (84.2–96.0)

80.0 (72.2–87.2)

88.2 (81.7–94.7)

 > 20 mm

0.841 (0.760–0.923)

76.9 (68.2–85.6)

81.7 (73.9–89.5)

67.7 (58.1–77.3)

83.1 (69.3–90.7)

65.6 (55.8–75.4)

All masses

0.862 (0.810–0.914)

81.5 (76.0–87.0)

79.3 (73.5,85.1)

83.5 (78.2–88.8)

82.0 (76.5–87.5)

81.0 (75.4–86.6)

US + S-Detect

All masses

0.911 (0.859–0.952)

85.2 (80.1–90.3)

93.5 (90.0–97.0)

77.3 (71.3–83.3)

79.6 (73.9–85.3)

92.6 (88.9–96.3)

P*

 < 0.001

0.290

 < 0.001

0.280

0.670

0.030

US + MFI

All masses

0.896 (0.852–0.939)

81.5 (76.0–87.0)

94.6 (91.4,97.8)

69.1 (62.6–75.6)

74.4 (68.2–80.6)

93.1 (89.5–97.2)

P*

 < 0.001

 > 0.999

 < 0.001

0.020

0.190

0.020

US + SR

All masses

0.886 (0.937–0.935)

82.5 (77.1–87.9)

79.3 (73.5,85.1)

85.6 (80.6–90.6)

83.9 (78.7–89.1)

81.4 (75.9–86.9)

P*

 < 0.001

0.915

 > 0.999

0.690

0.740

0.950

US + S-Detect + MFI

All masses

0.922 (0.884–0.960)

88.4 (83.8–93.0)

96.7 (94.1–99.3)

80.4 (74.8–84.0)

82.4 (77.0–87.8)

96.3 (93.6–99.0)

P*

 < 0.001

0.292

 < 0.001

0.575

0.944

0.002

US + S-Detect + SR

All masses

0.914 (0.874–0.954)

86.8 (82.0–91.6)

90.2 (86.0–94.4)

83.5 (78.2–88.8)

83.8 (78.5–89.1)

90.0 (85.7–94.3)

P*

 < 0.001

0.567

0.040

 > 0.999

0.741

0.081

US + MFI + SR

All masses

0.923 (0.884–0.962)

85.2 (80.1–90.3)

91.3 (87.3–95.3)

79.4 (73.6–85.2)

80.8 (75.2–86.4)

90.6 (86.4–94.8)

p*

 < 0.001

0.397

0.022

0.460

0.824

0.066

US + S-Detect + MFI + SR

 ≤ 20 mm

0.955 (0.917–0.994)

90.8 (85.1–96.5)

96.9 (93.4–100.4)

87.9 (81.4–94.4)

79.5 (71.5–87.5)

98.3 (95.7–100.9)

 > 20 mm

0.909 (0.843–0.975)

90.1 (84.0–96.2)

98.3 (95.7–100.9)

74.2 (65.2–83.2)

88.1 (81.3–94.9)

95.9 (92.0–99.8)

All masses

0.939 (0.905–0.974)

90.5 (86.3–94.7)

97.8 (95.7–99.9)

83.5 (78.2–88.8)

84.9 (79.8–90.0)

97.6 (95.5–99.7)

P*

 < 0.001

0.350

 < 0.001

 > 0.999

0.590

 < 0.001

  1. US: ultrasonography; MFI: microvascular flow index; SR: strain ratio; AUC: area under the receiver operating characteristic curve; PPV: positive predictive value; NPV: negative predictive value
  2. *Comparison with BI-RADS in entire cohort
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