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Table 4 Magnetic resonance spectroscopy findings in the included patients and control groups

From: Differentiating multiple sclerosis from cerebral small vessel disease using diffusion tensor imaging and magnetic resonance spectroscopy on normally appearing thalami

 

RRMS group (n = 30) [mean ± SD]

CSVD group (n = 30) [mean ± SD]

Control group (n = 30) [mean ± SD]

RRMS vs. CSVD P-value

RRMS vs. controls P-value

CSVD vs. controls P-value

NAA

Rt

8.5 ± 1.18

9.1 ± 1.1

10.3 ± 1.3

0.078

 < 0.001*

 < 0.001*

 

Lt

8.2 ± 1

9 ± 1.1

10.2 ± 1.1

0.004*

 < 0.001*

 < 0.001*

Cr

Rt

5 ± 0 .6

4.9 ± 0.5

5.1 ± 0.6

0.280

0.893

0.225

Lt

4.9 ± 0.6

5 ± 0.65

5.1 ± 0.5

0.403

0.111

0.442

Cho

Rt

4 ± 0.7

3.8 ± 0.6

3.9 ± 0.8

0.379

0.639

0.680

Lt

4.1 ± 0.66

3.7 ± 0.8

4 ± 0.85

0.090

0.699

0.188

NAA/Cr

Rt

1.7 ± 0.35

1.9 ± 0.3

2 ± 0.3

0.087

 < 0.001*

0.044*

Lt

1.7 ± 0.3

1.8 ± 0.3

2 ± 0.35

0.182

0.001*

0.036*

NAA /Cho

Rt

2.2 ± 0.6

2.4 ± 0.4

2.7 ± 0.7

0.322

0.001*

0.018*

Lt

2.1 ± 0.44

2.5 ± 0.5

2.7 ± 0.8

0.011*

 < 0.001*

0.239

MI

Rt

1.4 ± 0.45

1.5 ± 0.35

1.3 ± 0.56

0.332

0.566

0.124

Lt

1.5 ± 0.37

1.5 ± 0.4

1.4 ± 0.4

0.530

0.238

0.072

  1. *P value is considered significant at ≥ 0.05
  2. Cho Choline, Cr Creatine, MI Myo-inositol, NAA N-Acetyl aspartate, RRMS Relapsing–remitting multiple sclerosis, CSVD Cerebral small vessel disease, SD Standard deviation
  3. A P-value < 0.05 is considered significant