Table 5 Cut-off, sensitivity, specificity, positive predictive value, and negative predictive value of MRI parameters (on the left side) in the detection of RRMS (compared with controls)
LT FA | LT ADC | LT NAA | LT NAA/Cho | LT NAA/Cr | |
|---|---|---|---|---|---|
Cut off | > 280 | ≤ 740 | ≤ 9.01 | ≤ 2.48 | ≤ 1.82 |
P-value | < 0.001* | 0.767 | < 0.001* | < 0.001* | < 0.001* |
AUC | 0.888 | 0.523 | 0.897 | 0.775 | 0.761 |
Sensitivity (95% CI) | 83.33 (65.3–94.4) | 50.0 (31.3–68.7) | 86.6 (69.3–96.2) | 86.67 (69.3–96.2) | 66.6 (47.2–82.7) |
Specificity (95% CI) | 90.0 (73.5–97.9) | 66.67 (47.2–82.7) | 86.6 (69.3–96.2) | 56.6 (37.4–74.5) | 66.67 (47.2–82.7) |
PPV (95% CI) | 89.3 (73.8–96.1) | 60.0 (44.7–73.6) | 86.7 (72.1–94.2) | 66.7 (56.5–75.5) | 66.7 (53.2–77.9) |
NPV (95% CI) | 84.4 (70.6–92.4) | 57.1 (46.2–67.4) | 86.7 (72.1–94.2) | 81.0 (61.8–91.8) | 66.7 (53.2–77.9) |