Table 7 Cut off, sensitivity, specificity, positive predictive value, and negative predictive value of MRI parameters (on the left side) in the detection of CSVD (compared with controls)
LT FA | LT ADC | LT NAA | LT NAA/Cho | LT NAA/Cr | |
|---|---|---|---|---|---|
Cut off | ≤ 255 | > 786 | ≤ 9.24 | ≤ 2.8 | ≤ 1.86 |
P-value | < 0.001* | < 0.001* | < 0.001* | 0.540 | 0.024* |
AUC | 0.823 | 0.992 | 0.777 | 0.593 | 0.659 |
Sensitivity (95% CI) | 80.0 (61.4–92.3) | 93.3 (77.9–99.2) | 70.0 (50.6–85.3) | 76.6 (57.7–90.1) | 56.6 (37.4–74.5) |
Specificity (95% CI) | 73.3 (54.1–87.7) | 100.0 (88.4–100.0) | 86.6 (69.3–96.2) | 40.0 (22.7–59.4) | 56.6 (37.4–74.5) |
PPV (95% CI) | 75.0 (61.7–84.8) | 199 (85–100) | 84.0 (67.2–93.1) | 56.1 (47.3–64.5) | 56.7 (43.9–68.6) |
NPV (95% CI) | 78.6 (63.5–88.6) | 93.7 (79.7 -98.3) | 74.3 (62.2–83.6) | 63.2 (43.9–78.9) | 56.7 (43.9–68.6) |