Table 8 Cut off, sensitivity, specificity, positive predictive value, and negative predictive value of MRI parameters (on the Rt side) in detection of CSVD disease (compared with controls)
RT FA | RT ADC | RT NAA | RT NAA/Cho | RT NAA/Cr | |
|---|---|---|---|---|---|
Cut off | ≤ 253 | > 785 | ≤ 9.86 | ≤ 2.9 | ≤ 2 |
P-value | < 0.001* | < 0.001* | < 0.001* | 0.040* | 0.009* |
AUC | 0.879 | 0.987 | 0.763 | 0.647 | 0.680 |
Sensitivity (95% CI) | 86.67 (69.3(96.2) | 90.0 (73.5–97.9) | 86.6 (69.3–96.2) | 90.0 (73.5–97.9) | 83.3 (65.3–94.4) |
Specificity (95% CI) | 80.0 (61.4–92.3) | 100.0 (88.4–100.0) | 60.0 (40.6–77.3) | 36.6 (19.9–56.1) | 46.6 (28.3–65.7) |
PPV (95% CI) | 81.2 (67.6–90.0) | 100.0 (88.4–100.0) | 68.4 (57.8–77.4) | 58.7(51.4–65.7 | 61.0 (51.9—69.4) |
NPV (95% CI) | 85.7 (70.3–93.8) | 90.9 (77.4–96.7) | 81.8 (63.3–92.1) | 78.6 (53.2–92.2) | 73.7 (53.6–87.2) |