Glioma grading using an optimized T1-weighted dynamic contrast-enhanced magnetic resonance imaging paradigm

Egyptian Journal of Radiology and Nuclear Medicine

Table 4 The accuracy, sensitivity, specificity, PPV, NPV, and Kappa coefficient of permeability (Ktrans, Kep, etc.) indices for differentiation between the different grades of gliomas

		Threshold	Accuracy (%)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Kappa Coeff
Ktrans (mL/g min)	GII versus GIII	0.028	76.92	70	81.25	70	81.25	0.76
	GII versus GIV	0.15	100	100	100	100	100	1
	GIII versus GIV	0.2	84.21	88.89	80	80	88.89	0.83
	LGG versus HGG	0.025	82.86	84.21	81.25	84.21	81.25	0.82
Kep (1/min)	GII versus GIII	0.23	53.85	70	43.75	43.75	70	0.51
	GII versus GIV	0.42	76	77.78	75	63.64	85.71	0.75
	GIII versus GIV	0.49	63.16	66.67	60	60	66.67	0.61
	LGG versus HGG	0.29	77.14	78.95	75	78.95	75	0.76
Vp (mL/g)	GII versus GIII	0.045	65.38	80	56.25	53.33	81.82	0.63
	GII versus GIV	0.16	100	100	100	100	100	1
	GIII versus GIV	0.19	84.21	88.89	80	80	88.89	0.83
	LGG versus HGG	0.065	74.29	73.68	75	77.78	70.59	0.73
Ve (mL/g)	GII versus GIII	0.067	57.69	60	56.25	46.15	69.23	0.55
	GII versus GIV	0.28	88	88.89	87.5	80	93.33	0.87
	GIII versus GIV	0.25	78.95	100	60	69.23	100	0.78
	LGG versus HGG	0.15	62.86	68.42	56.25	65	60	0.60

The discriminative thresholds of permeability indices were also listed in the first column