Glioma grading using an optimized T1-weighted dynamic contrast-enhanced magnetic resonance imaging paradigm

Egyptian Journal of Radiology and Nuclear Medicine

Table 5 The accuracy, sensitivity, specificity, PPV, NPV, and Kappa coefficient of semi-quantitative (IAUC₆₀, Peak, etc.) indices for differentiation between the different grades of gliomas

		Threshold	Accuracy (%)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Kappa Coeff
IAUC₆₀ (mmol Sec/L)	GII versus GIII	3.22	73.08	80	68.75	61.54	84.62	0.71
	GII versus GIV	8.85	100	100	100	100	100	1
	GIII versus GIV	11.47	84.21	100	70	75	100	0.83
	LGG versus HGG	4.49	82.86	73.68	93.75	93.33	75	0.82
Wash-in rate (mmol/L Sec)	GII versus GIII	0.0043	65.38	80	56.25	53.33	81.82	0.63
	GII versus GIV	0.0081	84	77.78	87.5	77.78	87.5	0.83
	GIII versus GIV	0.015	78.95	66.67	90	85.71	75	0.78
	LGG versus HGG	0.0054	62.86	68.42	56.25	65	60	0.60
Peak (mmol/L)	GII versus GIII	0.086	65.38	70	62.5	53.85	76.92	0.63
	GII versus GIV	0.22	96	88.89	100	100	94.12	0.96
	GIII versus GIV	0.34	78.95	88.89	70	72.73	87.5	0.78
	LGG versus HGG	0.110	85.71	84.21	87.5	88.89	82.35	0.85

The discriminative thresholds of semi-quantitative indices were also listed in the first column