Table 2 Miller-Payne grading system for histopathologic response evaluation [14]
Miller-Payne system | Histopathologic findings |
|---|---|
Grade 1 | No change or some alteration to individual malignant cells, but no reduction in overall cellularity |
Grade 2 | A minor loss of tumor cells, but overall, cellularity is still high, up to 30% loss |
Grade 3 | Between an estimated 30% and 90% reduction in tumor cells |
Grade 4 | A marked disappearance of tumor cells such that only small clusters or widely dispersed individual cells remain > 90% loss of tumor cells |
Grade 5 | No malignant cells identifiable in sections from the site of the tumor |