Skip to main content

Lymph nodes in the head and neck cancer: would diffusion-weighted magnetic resonance imaging solve the diagnostic dilemma?



Head and neck cancer has been labeled as the fifth most common cancer. Lymph node (LN) metastases were reported as the most important predatory factor for diagnosis and selection of suitable treatment. Diffusion-weighted (DW) magnetic resonance (MR) imaging is a very important tool that gives quantitative data in several compartments. This work aims to evaluate the diagnostic value of diffusion-weighted as a part of the magnetic resonance imaging in patients with head and neck cancer to allow differentiation of lymph nodes, cancer staging, assessment of recurrence, and evaluation of the effects of oncologic therapy.


The size of pathologically proven benign LNs ranged from 1 to 3 cm (1.71 ± 0.724) and malignant LNs ranged from 1.1 to 5.6 cm (2.54 ± 0.92) (P = 0.0103). The ADC value for benign LNs ranged from 1.26 × 10−3 to 2.49 × 10−3 (mean 1.98 × 10−3 ± 0.32 × 10−3), and malignant LNs from 0.608 × 10−3 to 2.1 × 10−3 (mean 0.971 × 10−3 ± 0.305 × 10−3) (P < 0.001) with sensitivity and a specificity of 94% and 100% respectively. The ADC value for metastatic LNs ranged from 0.70 × 10−3 to 2.10 × 10−3 (1.08 × 10−3 ± 0.31 × 10−3) while lymphomatous nodes ranged 0.608 × 10−3 to 1.16 × 10−3 (0.78 × 10−3 ± 0.17 × 10−3). In this study, a significant statistical difference was also observed between the ADC value of the SCC and lymphomatous LN (P = 0.0034) with sensitivity and a specificity of 90% and 75% respectively.


Diffusion-weighted MR imaging is an effective assist in differentiating benign and malignant lymph nodes. It acts as an indicator for recovery or recurrence after chemotherapy and radiotherapy.


Lymph nodes are widely distributed, and our body has about 800 lymph nodes, about 300 are found in the neck [1]. Enlarged abnormal cervical lymph nodes are indicator for several pathological conditions including tumors, infection, and inflammation [2]. Cervical lymphadenopathy is a term to describe the conditions in which lymph nodes become abnormal in size (measuring more than 1 cm in diameter), consistency, and number [3, 4]. DWI is recognized as a sensitive marker in distinguishing between benign and malignant head and neck cancer, treatment protocol, and follow-up [5, 6].

Tumors in the head and neck are including cancers in various anatomical sites including tumors of the oral cavity, nasopharynx, paranasal sinuses, and larynx [7]. Globally, tumors in the head and neck are recognized as one of the top five tumor types. They are accounting for about 3 to 4% of the overall malignancies. So far, tumors in the head and neck are responsible for more than 700,000 cases and more than 350,000 deaths annually [8, 9]. About 95% of head and neck cancer begins in squamous cells and known as head and neck squamous cell carcinoma (HNSCC). Alcohol and tobacco are the major risk factors for causing and developing this type of tumor; recently, the Epstein-Barr virus (EBV) and the human papillomavirus (HPV) are also considered other risk factors for the nasopharyngeal and oropharyngeal cancers respectively [7, 10]. Computed tomography (CT), routine magnetic resonance imaging, and laryngoscopy are the most commonly used diagnostic techniques for that type of cancer [11]. MRI sequences provided precise data regarding tumor size, site, and the head and cancer morphology. The diffusion-weighted imaging as a part of the MRI technique being a non-invasive tool without the definite need for administration of intravenous contrast agent had provided a reliable ability in the differentiation between the benign and malignant tissues [12].

The main objective of this study was to evaluate the role of diffusion-weighted magnetic resonance imaging in differentiating between the benign and the malignant lymph nodes in patients with head and neck malignancy as well as to evaluate its role as regards the cancer staging, recurrence, as well as evaluation of the effects of oncologic therapy.


This study was conducted on 40 patients referred to the radiodiagnosis and imaging department of our institution, between March and September 2018. The patients included in this study were from the outpatient clinics suffering from palpable cervical lymph nodes with unknown primary malignancy or having a known head and neck cancer. This study is IRB approved with a provided written consent given by all patients before proceeding with examination. The exclusion criteria were non-confirmed histopathological results and absolute contraindications to MRI such as cardiac pacemakers.

The full socio-demographic and clinical data including age, sex, and general examination including local head and neck examination as well as the laboratory biochemical parameters such as kidney function parameters were all recorded.

All MR examinations were acquired by a 1.5-T whole-body system Philips machine. All the patients were scanned in the supine position utilizing a head and neck surface coil for both the conventional imaging and diffusion-weighted MR imaging. The conducted sequences included the axial and coronal T2-weighted fast spin-echo sequences, followed by axial T1-weighted pre and post-fat-suppression fast spin-echo sequences with given parameters summarized in Table 1.

Table 1 MR imaging parameters

The diffusion acquisition was obtained using b values 0, 500, and 1000 s/mm2. We used a high b value of 1000 s/mm2 to give an accurate assessment at sufficiently high signal-to-noise ratios. The diffusion-weighted images were generated by single-shot echo-planar imaging spin-echo technique with the given parameters: TR/TE, 2000/50–60; slice thickness, 5 mm; matrix, 256 × 256; FOV, 220 mm; and flip angle, 90°. The ADC map was generated by using the acquired images, and the apparent diffusion coefficient (ADC) was calculated monoexponentially via the scanner software.

The post-contrast sequence images were obtained after Gadoteric acid IV injection given at a rate of 2 ml/s. Post-contrast T1-weighted imaging with fat suppression was performed in the axial and coronal planes.

The lymph nodes were assessed based on the internationally accredited standards for the assessment of the anatomical imaging data. Firstly, we detected the anatomical location of enlarged lymph nodes and characterized them by the numerical grouping system. Then, the size and morphological characteristics of lymph nodes as regard to their parenchymal homogeneity and contrast enhancement were reported. The DW images with their corresponding ADC maps were carefully evaluated in concurrence. Through the obtained b value of 0 s/mm2 images, the lymph nodes were adequately localized. Multiple (2–3) regions of interests (ROIs) were put over the lymph nodes that were depicted on the b value 0 images based on visual assessment in order to obtain quantitative assessment; those regions were automatically transferred to the other b value images. For all solid lymph nodes, the regions of interest were put anywhere along the center and/or periphery of the examined lymph node. For other nodes showing mixed solid and necrotic components, the regions of interest was put on the solid portion. The mean ADC value of all the examined ROIs was used for the analysis and was known to be the mean ADC for the lesion.

Finally, the radiologic findings were correlated with the histopathologic results as a reference standard. Histopathologic analysis was done in all patients (3 patients underwent excisional biopsy while 37 patients underwent fine-needle aspiration cytology (FNAC)).

The optimal ADC threshold with b values 0 and 1000 for discriminating the benign from the malignant lymph nodes was established via using receiver operating characteristic analysis. The sensitivity and specificity of the ADC with b values 0 and 1000 were subsequently calculated.

The provided data was further analyzed via the Statistical Package for Social Sciences (SPSS) software. P < 0.05 was regarded as indicating a significant difference.


Among the study population, 22 (55%) were males and 18 (45%) were females, their ages ranged between 11 and 67 years (mean age 39.75 ± 17.6), and a total pathological lymph nodal mean size of 2.21 ± 0.95 cm (range 1–5.6 cm). The clinical presentation of the study patients revealed that 17 (43%) patients who came with appreciable cervical lymph nodes had no identified primary and had US neck or CT prior to their MRI study; 19 (47%) patients who reported to have head and neck cancer had come for staging and treatment preparation while 4 (10%) patients who came for their post-operative follow-up (thyroidectomy and radioactive iodine or hemiglossectomy) had undergone neck US prior to MRI neck examination.

Histopathological analysis

Figure 1 shows the subgroups of lymph nodes according to the histopathology. The image evaluation showed that 10 cases were pathologically proven to be benign lymphadenopathy with the size ranged between 1 and 3 cm (1.71 ± 0.724), including acute reactive lymphadenitis, chronic granulomatous, chronic non-specific inflammation, and hyperplasia of the reactive lymphoid tissue, and 30 malignant lymph nodes; the malignant nodes measured between 1.1 and 5.6 cm (2.54 ± 0.92) include 20 metastatic LNs from head and neck malignancy and 10 primary lymphomas; the difference between the benign and malignant nodes as regard their size was statistically significant (P value = 0.0103) (Fig. 2).

Fig. 1
figure 1

Pie chart showing the subgroups of lymph nodes according to the histopathology

Fig. 2
figure 2

Boxplot of LN size in benign versus malignant lymph nodes

Parenchymal architecture

Table 2 showed the parenchymal architecture of malignant and benign lymphadenopathy. The ADC value for benign LNs ranged between 1.26 × 10−3 and 2.49 × 10−3 (1.98 × 10−3 ± 0.32 × 10−3). The ADC value for malignant LNs ranged between 0.608 × 10−3 and 2.1 × 10−3 (0.971 × 10−3 ± 0.305 × 103). There was a statistically significant difference between the benign and malignant nodes as regards their ADC with P < 0.001 (Fig. 3). Further analysis of the ADC values in patients with metastatic LNs and lymphoma revealed that the ADC value for metastatic LNs ranged between 0.70 × 10−3 and 2.10 × 10−3 (1.08 × 10−3 ± 0.31 × 10−3). The ADC value for lymphomatous LNs ranged between 0.608 × 10−3 and 1.16 × 10−3 (0.78 × 10−3 ± 0.17 × 10−3). The discrepancy was statistically significant with P = 0.0034 (Fig. 4).

Table 2 The parenchymal architecture of malignant and benign lymphadenopathy
Fig. 3
figure 3

Boxplot of ADC values in benign versus malignant lymph nodes

Fig. 4
figure 4

Interval plot of ADC values of benign LN, metastatic LN, and lymphomatous LN

Receiver operating characteristic analysis

Figure 5 shows the analysis of the ROC curve for ADC values in benign vs. malignant LNs revealed a sensitivity of 90.00% with 100% specificity for discrimination between the benign and malignant nodes for ADC value ≤ 1.3 × 10−3. ROC curve analysis of ADC values in metastasis vs. lymphoma revealed a sensitivity of 90.00% with 75% specificity for differentiation between the metastatic and lymphomatous nodes for ADC value ≤ 0.9 × 10−3. Figures 6, 7, 8, and 9 showed 4 different cases with its final diagnosis and ADC values.

Fig. 5
figure 5

a ROC curve analysis for ADC values in benign versus malignant LN. b ROC curve analysis for ADC values in metastatic versus lymphomatous LN

Fig. 6
figure 6

Fifty-five-year-old male with a known history of laryngeal carcinoma a axial T2, b coronal T2 WIs showing multiple enlarged left deep cervical and supraclavicular lymph nodes exhibiting intermediate to high T2 signal. c Post-contrast coronal T1 WIs showing heterogeneous contrast uptake and breaking down. d DWIs b 1000 and e ADC map showing hyperintense LNs in diffusion images corresponding to low signal in ADC map with an ADC value varying from 0.893 × 10−3 to 0.927 × 10−3 mm2/s; the possibility of metastatic nodal deposits is considered which was proven by biopsy

Fig. 7
figure 7

Forty-five-year-old male, known case of non-Hodgkin lymphoma with enlarged right deep cervical lymph nodes. a Axial STIR WIs and b coronal T2 WIs showing high signal of the enlarged nodes. c Post-contrast sagittal T1 WIs showing heterogeneous contrast uptake. d DWIs b 1000 and e ADC map showing hyperintense LNs in diffusion WIs corresponding to low signal in ADC map, with an ADC value of 0.723 × 10−3 mm2/s; the possibility of lymphomatous nodal infiltrate was considered and proven by biopsy

Fig. 8
figure 8

Sixty-year-old female known case of squamous cell carcinoma of the tongue a axial STIR WIs and b coronal T2 WIs showing few enlarged right cervical lymph nodes with high T2 and STIR signal. c Post-contrast sagittal T1 WIs showing heterogeneous contrast uptake and a large area of breaking down. d DWIs b 1000 and e ADC map showing hyperintense LNs in diffusion WIs and corresponding intermediate to low signal in ADC map; with an ADC value of 1.127 × 10−3 mm2/s; the possibility of metastatic nodal deposits is considered which was proven by biopsy

Fig. 9
figure 9

Thirty-three-year-old patient presenting with bilaterally enlarged deep cervical lymph nodes much more extensive on the right a axial T2 WIs and b coronal T2 WIs showing intermediate signal of the enlarged lymph nodes. c Post-contrast sagittal T1 WIs showing fair homogenous contrast uptake in the post-contrast sequences. d DWIs b 1000 and e ADC map showing partially hyperintense LNs in diffusion images corresponding to low signal in ADC map, with an ADC value of 1.3 × 10−3 mm2/s. The biopsy was negative for metastatic nodal deposits, proven to be benign lymphadenopathy of granulomatous nature


DW-MRI (diffusion-weighted magnetic resonance imaging) is an effective non-invasive imaging technique for tissue characterization. DWI has been considered as a cancer biomarker and could distinguish benign from malignant tumors [13]. Our research aimed to establish the diagnostic validity of the diffusion-weighted magnetic resonance imaging for the distinction between benign and malignant lymph nodes via comparing the ADC values, as solving out this diagnostic problem is mandatory for the management of the patients.

Our study revealed that the prevalence of tumors in the head and neck was higher in males (55%) than females (45%) without significant differences, in agreement with Lambert et al. [14] who reported that males are highly affected than females, but with a significant difference, with a ratio ranging from 2 to 4 folds. Our study results showed that Hodgkin disease incidence is higher in young age groups, although the prevalence of non-Hodgkin disease among the elderly population was higher, with no significant difference. Our study findings are in line with previous studies which reported that Hodgkin lymphoma is higher in younger age groups [15,16,17].

Our analysis included 9 nodes less than 1 cm in their shortest axis diameter; 3/9 were metastatic and showed a pattern of restriction on DWIs and opposing low ADC value. On the other hand, these 9 nodes displayed no definite morphological characteristics of malignancy, such as necrosis and ill-defined margins in the conventional MRI sequences, and classification of metastatic nodes would have been very unlikely, in agreement with ElSaid et al. [18] who reported that all metastatic lymph nodes less than 1 cm were missed due to anatomical MR imaging criteria based on size.

In the present study, on the contralateral side of the primary tumor, 1/3 metastatic differentiated squamous cell carcinoma lymph nodes (< 1 cm) were found, in agreement with Vandecaveye et al. [19] and ElSaid et al. [18] who reported the degree to which DWI changes nodal differentiation efficacy via depicting subcentimetric nodal metastases may affect the clinical management. Our study showed that the pathologically proven malignant lymph nodes (29 out of 30 cases) showed increased signal in b 1000, and low signal in the corresponding ADC maps, the inflammatory diseases (5 out of 6 cases), and reactive lymphoid hyperplasia (4 out of 4 cases) showed signal intensity reduction for increased b values (b = 1000) and intermediate signal intensity on ADC maps representing facilitated diffusion. Our study findings agreeing with Youssef et al. [20] and Abou khadrah and Imam [12] that the DWI with ADC mapping were useful as non-invasive tools for distinguishing between the benign and malignant solid head and neck lesions by using b values 800 and 1000. The malignant lymph nodes in our sample had significantly lower ADCs than benign lymph nodes. The ADC measurements of benign and malignant lymph nodes varied considerably with a P < 0.001, these results agree with Youssef et al. [20]. In our research, the mean ADC value of the 30 malignant lymph nodes was 0.971 ± 0.305 × 10−3 mm2/s, while on the other hand, the mean ADC value of the 10 benign lymph nodes was 1.98 ± 0.33 ± 3 mm2/s with the threshold ADC value for separating malignant from benign nodes obtained from the receiver characteristic analysis being 1.30 × 10−3 mm2/s with 94% sensitivity and 100% specificity. In agreement with Abou khadrah and Imam [12] who recorded 94% accuracy in characterizing the metastatic lymph nodes using a threshold of 1.0210−3 mm2/s. The mean ADC values recorded for benign and metastatic lymph nodes were 1. 24 ± 0.1610−3 mm2/s and 0.78 ± 0.0910−3 mm2/s respectively.

In our research, malignant lymph nodes had been subdivided into subgroups of metastatic carcinoma and lymphoma based upon the histopathology. An attempt was made to distinguish between them according to their ADC values. The mean ADC value for metastatic carcinoma (1.079 × 10−3 mm2/s) was a little higher than that of the lymphoma (0.781 × 10−3 mm2/s). The ADC threshold value for metastatic differentiation from lymphomatous lymph nodes obtained from receiver operating characteristic (ROC) analysis was 0.9 × 10−3 mm2/s with 90% sensitivity and 75% specificity,

Thirty-four true-positives and 6 false-positives were shown via statistical data, providing a sensitivity of 100%, and specificity of 85%; these results agree with Usama and Ahmed [21] who reported the same results of the present study.

Limitations of this study

First, our analysis has some drawbacks, such as being a small cohort study. Also, our statistical tests were carried out on the number of nodes involved, not the number of patients. Second, for several reasons, we did not provide standardized ADCs: (1) As far as we know, the value of using standardized, rather than absolute, ADCs in head and neck imaging at DW was never reported. Unlike the brain, the region of the head and neck is distinguished by an extremely heterogeneous diffusivity of the tissues due to the presence of tissues of distinctly different histological origins. The spine is also the most appropriate reference tissue for normalization. However, echo-planar imaging of the spinal cord is hampered by strong susceptibility influences caused mainly by the osseous elements of the spinal column, which induce additional variability in ADC calculations. (2) The promising results of the current study, obtained using absolute ADCs, may suggest that normalization is not necessary, thus facilitating the implementation of DW imaging into routine clinical practice.


Our study concluded that diffusion MR imaging may be considered a fundamental supporting method in the diagnosis and classification of benign and malignant lymph nodes, can vary to a lesser extent between the forms of malignant lymphadenopathy, and may be recognized as a predictor of post-chemo and radiotherapy improvement and recurrence.

Availability of data and materials

All the datasets used and analyzed in this study are available with the corresponding author on reasonable request.



Apparent diffusion coefficient


Diffusion weighted


Diffusion-weighted imaging


Epstein-Barr virus


Fine-needle aspiration cytology


Head and neck squamous cell carcinoma


Human papillomavirus


Institutional review board


Lymph node


Magnetic resonance imaging


Receiver operating characteristic


Region of interest


  1. Chen C-C, Lin J-C, Chen K-W (2015) Lymph node ratio as a prognostic factor in head and neck cancer patients. Radiat Oncol 10(1)

  2. Shrivastava, Jyoti. (2019): Spectrum of lesions of superficial lymph nodes on FNAC: a simple, effective tool for diagnosis. 5. 161-163.

  3. Anne R Wilkinson, Sadhana D Mahore, Sabiha A. Maimoon (2012): FNAC in the diagnosis of lymph node malignancies: a simple and sensitive tool. Indian J Med Paediatr Oncol 2012; 33(1):21-24.

  4. Shahrad Mohseni MD, Abolfazl Shojaiefard MD, Zhamak Khorgami MD, Shahriar Alinejad MD, Ali Ghorbani MD, and Ali Ghafouri MD (2014): Peripheral lymphadenopathy: approach and diagnostic tools, Iran. J Med Sci. 2014 Mar; v 39(2 Suppl): 158–170

  5. Dawood HA, Hassan TA, Mohey N (2014) Value of combined real time sonoelastography and apparent diffusion coefficient value measurement in differentiation of enlarged neck lymph nodes. Egypt J Radiol Nucl Med 45:387–394

    Article  Google Scholar 

  6. Ali TF, El Hariri MA (2017) Combined diffusion-weighted MRI and MR spectroscopy: feasibility to improve the MRI capability in differentiation between benign and malignant neck lymphadenopathy. Egypt J Radiol Nucl Med 48:97–106

    Article  Google Scholar 

  7. Aboagye E, Agyemang-Yeboah F, Duduyemi BM, Obirikorang C (2019) Human papillomavirus detection in head and neck squamous cell carcinomas at a tertiary hospital in Sub-Saharan Africa. Sci World J 2019:1–6

    Article  Google Scholar 

  8. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, et al. (2018): Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68:394-424.

  9. Alamolhoda F, Faeghi F, Bakhshandeh M, Ahmadi A, Sanei Taheri M, Aabbasi S (2019) Diagnostic value of diffusion weighted magnetic resonance imaging in evaluation of metastatic neck lymph nodes in head and neck cancer: a sample of Iranian patient. Asian Pacific journal of cancer prevention: APJCP 20(6):1789–1795

    Article  CAS  Google Scholar 

  10. Wołącewicz M, Becht R, Grywalska E, Niedźwiedzka-Rystwej P (2020) Herpesviruses in head and neck cancers. Viruses 12(2):172

    Article  Google Scholar 

  11. Zhang, S., Zhou, S., Shang, D., Bao, Y., Ruan, L., & Wu, T. (2018): The diagnostic role of diffusion-weighted magnetic resonance imaging in hypopharyngeal carcinoma.

  12. Abou khadrah RS, Imam HH (2019) Multiple b values of diffusion-weighted magnetic resonance imaging in evaluation of solid head and neck masses. Egypt J Radiol Nucl Med 50:54 (2019)

    Article  Google Scholar 

  13. Sabri YY, Nossair EZB, Assal HH et al (2020) Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions. Egypt J Radiol Nucl Med 51:32

    Article  Google Scholar 

  14. Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R. (2011): Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol 2011; 23:633.

  15. Punnett A, Tsang RW, Hodgson DC. (2010): Hodgkin lymphoma across the age spectrum: epidemiology, therapy, and late effects. Semin Radiat Oncol 2010; 20:30–44.

  16. Ansell SM. (2016): Hodgkin lymphoma: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol 2016; 91:434–442.

  17. Zhou L, Deng Y, Li N et al (2019) Global, regional, and national burden of Hodgkin lymphoma from 1990 to 2017: estimates from the 2017 Global Burden of Disease study. J Hematol Oncol 12:107 (2019)

    Article  Google Scholar 

  18. ElSaid NAE, Nada OMM, Habib YS, Semeisem AR, Khalifa NM (2014) Diagnostic accuracy of diffusion weighted MRI in cervical lymphadenopathy cases correlated with pathology results. The Egyptian Journal of Radiology and Nuclear Medicine 45(4):1115–1125

    Article  Google Scholar 

  19. Vandecaveye V, De Keyzer F, Vander Poorten V, Dirix P, Verbeken E, Nuyts S, Hermans R (2009) Head and neck squamous cell carcinoma: value of diffusion-weighted MR imaging for nodal staging. Radiology 251(1):134–146

    Article  Google Scholar 

  20. Youssef H, Elzorkany M, Hussein S, Taymour T, Helmy M (2019) Evaluation of mediastinal lymphadenopathy by diffusion weighted MRI; correlation with histopathological results. Advances in Respiratory Medicine 87:175–183

    Article  Google Scholar 

  21. Usama Elsaied Ghieda, Ahmed Abdul-Raheem Badr, (2020): Diffusion-weighted magnetic resonance imaging in characterization of neck lymph nodes in head and neck cancer, International Journal of Medical Imaging. Vol. 8, No. 1, 2020, pp. 6-15.

Download references


Not applicable.


Not applicable (no funding)

Author information

Authors and Affiliations



D.K.S. puts the idea of the study. MRI assessment and performed the statistical analysis. B.E.M participated in the study design and MRI assessment. B.D participated in data collection and clinical assessment of the patients. S.F.E is the editor of the manuscript. Participation in the study design, performed the MRI assessment. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Dalia K. Serour.

Ethics declarations

Competing interest

The authors declare that they have no financial or non-financial competing interest.

Ethics approval and consent to participate

Written informed consent was signed by all patients before the MRI examination. The study is approved by the medical committee of the faculty of medicine Cairo University in December 2017. Reference number not available.

Consent for publication

All adult patients included in this research (≥ 18 years of age) gave written informed consent to publish the data contained within this study. If the patient was younger than 18 years or unconscious and consent for publication was requested, written informed consent for the publication of data was given by his/her parent or legal guardian.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Serour, D.K., Mahmoud, B.E., Daragily, B. et al. Lymph nodes in the head and neck cancer: would diffusion-weighted magnetic resonance imaging solve the diagnostic dilemma?. Egypt J Radiol Nucl Med 51, 190 (2020).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: