- Case Report
- Open access
- Published:
Giant adrenal metastasis of malignant melanoma: impact of 18F-FDG PET/CT in early assessment of dramatic response to immunotherapy: case report
Egyptian Journal of Radiology and Nuclear Medicine volume 54, Article number: 158 (2023)
Abstract
Background
This case represents one of the largest adrenal metastases in the literature and highlights the importance of accurate imaging in clinical management of patients with advanced malignant melanoma.
Case presentation
A 67-year-old female with an ulcerated malignant melanoma presented with an asymptomatic 18-cm left adrenal mass on 18F-FDG PET/CT staging. After two cycles of combined systemic immunotherapy, an impressive shrinkage of the adrenal metastatic tumor was observed on 18F-FDG PET/CT imaging.
Conclusions
The case emphasizes the potential of 18F-FDG PET/CT as a functional imaging modality for accurate staging and precise early assessment of response to immunotherapy. Overall, this report highlights the importance of accurate imaging for the effective management of adrenal metastases in melanoma patients.
Background
Malignant melanoma is one of the most common primary sites for adrenal metastases [1, 2]. Adrenal metastases are often asymptomatic and mostly detected as a part of multiorgan metastases [3]. 18F-FDG PET/CT has demonstrated high overall accuracy in detecting distant metastases and, in combination with cerebral MRI, is the preferred imaging approach for staging metastatic melanoma [4]. Systemic mono- or combined immunotherapy (nivolumab plus ipilimumab) is currently considered an initial treatment option in unresectable, non-isolated adrenal metastases. Nivolumab plus ipilimumab is preferred therapy for aggressive feature disease [5,6,7]. To the best of our knowledge, this case presents one of the largest adrenal metastases based on the literature review up to 2023 [1, 8] with a remarkable response to two cycles of immunotherapy.
Case presentation
A 67-year-old female presented with cachexia and a left arm 5 cm skin ulcer. Two weeks after excision of ulcerated malignant melanoma, 18F-FDG PET/CT was performed for primary staging that revealed an 18F-FDG–avid 18-cm left adrenal mass, ascites, 18F-FDG–avid abdominopelvic lymph nodes and intramuscular right gluteal metastasis (Fig. 1A, D). Concurrent brain MRI showed metastatic lesions, most prominently a lesion in the left frontal lobe with surrounding edema (Fig. 1G). Combined immunotherapy with nivolumab and ipilimumab and stereotactic radiation for the brain were started. Evaluation of response to treatment with 18F-FDG PET/CT and brain MRI after two cycles of immunotherapy showed remarkably impressive shrinkage of the adrenal and brain metastatic lesions and complete resolution of the lymph node and muscular metastases (Fig. 1B, E, H). Subsequent follow-up conducted six months later demonstrated continued tumor shrinkage on 18F-FDG PET/CT and MRI (Fig. 1C, F, I).
Conclusions
Considering costs and immune-related adverse effects of these novel therapies, defining an accurate imaging modality for staging and interim assessment of the response to therapy is of great importance. Although this case shows the potential of 18F-FDG PET/CT for assessment of response to immunotherapy, to determine the role of 18F-FDG PET/CT during the treatment course of advanced melanoma, well-designed studies with standardized scanning protocols, including clinical parameters and comparison with other imaging modalities are needed.
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Abbreviations
- 18F-FDG:
-
2-[18F]Fluoro-2-deoxy-d-glucose
- PET/CT:
-
Positron emission tomography/computed tomography
- MRI:
-
Magnetic resonance imaging
References
Öz B et al (2019) Laparoscopic adrenalectomy for the treatment of isolated large adrenal gland metastases from malignant melanoma: a case report. Cureus 11(10):e6020
Spartalis E et al (2019) Metastatic carcinomas of the adrenal glands: from diagnosis to treatment. Anticancer Res 39(6):2699–2710
Dong A et al (2014) (18)F-FDG PET/CT of adrenal lesions. AJR Am J Roentgenol 203(2):245–252
Bisschop C et al (2020) Rational use of (18)F-FDG PET/CT in patients with advanced cutaneous melanoma: a systematic review. Crit Rev Oncol Hematol 153:103044
Ascierto PA et al (2019) Survival outcomes in patients with previously untreated BRAF wild-type advanced melanoma treated with nivolumab therapy: three-year follow-up of a randomized phase 3 trial. JAMA Oncol 5(2):187–194
Larkin J et al (2015) Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373(1):23–34
Pires da Silva I et al (2022) Clinical models to define response and survival with anti-PD-1 antibodies alone or combined with ipilimumab in metastatic melanoma. J Clin Oncol 40(10):1068–1080
Pramod SV et al (2020) The largest adrenal leiomyoma: a case report and literature review. Urol Case Reports 29:101106
Acknowledgements
Not applicable.
Funding
There were no sources of funding (institutional, private, and corporate financial support) for the work reported in this paper.
Author information
Authors and Affiliations
Contributions
The authors performed the PET/CT scan and wrote the manuscript. All authors read and approved the final manuscript. This manuscript was read and approved by all the authors, which represent our honest report.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
There was no conflict of interest in both the designing and accomplishment of this study.
Consent for publication
The authors confirm that the statements of written informed consent from legally authorized representatives/parents/guardians are available.
Competing interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Kalantari, F., Schweighofer-Zwink, G., Rendl, G. et al. Giant adrenal metastasis of malignant melanoma: impact of 18F-FDG PET/CT in early assessment of dramatic response to immunotherapy: case report. Egypt J Radiol Nucl Med 54, 158 (2023). https://doi.org/10.1186/s43055-023-01107-9
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s43055-023-01107-9