Correct staging of lung cancer is important because the treatment options and prognosis differ significantly according to stage. Understanding the advantages and disadvantages of the available methods for staging NSCLC is crucial to decision-making [10].
According to T staging
As regards chest wall and mediastinal invasion, in the current study, there was no mismatch between CT and PET –CT. This disagrees with Lardinois et al. [12] and De Wever et al. [13] who concluded that integrated PET/CT correctly predicted the T staging in patients with NSCLC in 86% of cases versus 68% with CT.
However, in this study, PET/CT allowed better discrimination between the tumor and the surrounding consolidative changes. This agrees with the study by De Wever et al. [13] who stated that PET/CT more accurately determined the T designation compared with CT alone. One of the advantages of PET/CT is in differentiating central tumors from post obstructive atelectasis because the tumor will often have increased FDG uptake compared with an atelectatic lung.
Regarding ipsilateral pulmonary nodules, this study revealed a mismatch between CT and PET-CT, with CT having false positive results in 9 cases. This caused PET-CT to downstage some patients. This is in keeping with the studies by Yi et al. [14] and Halley et al. [15],who concluded that PET-CT showed high sensitivity and specificity in differentiating benign from malignant pulmonary nodules more than 1 cm. It is also concordant with the study by Acker and Burrell [16] who stated that patients with negative (i.e. No FDG uptake) PET-CT nodules only need a follow-up. Among the cases downstaged with PET-CT, in only 1 case, the overall stage was changed and the patient became operable. In the remaining 8 cases, the overall stage was the same due to nodal and distant metastasis.
A study by Ma C et al. [17] reported the ability of PET-CT to detect recurrent laryngeal nerve invasion and to clarify the cause of associated hoarseness of voice in lung cancer patients. This is concordant with the current study, where PET-CT detected 4 cases of recurrent laryngeal nerve invasion, but CT detected only one case. However, on retrospective pattern, the invasion could be detected by CT. At FDG PET/CT, unilateral vocal cord paralysis appeared as asymmetric increased uptake in the normal cord due to compensation by and hypertrophy of the non-paralyzed muscles (Fig. 1). On retrospective analysis of the CT, vocal cord paralysis was demonstrated as ipsilateral piriform sinus dilatation and medial rotation and thickening of the aryepiglottic fold.
Regarding the 3 cases of recurrent laryngeal nerve paralysis upstaged by PET-CT, their overall stage remained the same, due to nodal and distant metastasis in two cases. The remaining one showed no change and was staged as T4 according to tumor size.
According to N staging
Accurate mediastinal lymph node staging is particularly important, as in many cases, the status of these nodes will determine whether surgical resection of lung cancer is possible [18].
This study agrees with Darling et al. [19] and Perigaud et al. [20] that PET-CT is a valuable tool in mediastinal lymph node staging but it should be considered as a good negative modality and when positive mediastinal lymph nodes are detected, invasive mediastinal staging must be performed. Multiple studies Wever et al. [21], Lardinois et al. [12], Jeon et al. [22], Liu et al. [23], and Yang et al. [24] reported that PET-CT is more accurate than PET or CT alone in mediastinal lymph node staging.
In the current study, PET-CT upstaged 2 cases with ipsilateral hilar LNs, 4 cases with ipsilateral mediastinal LNs, 3 cases with contralateral LNs (Fig. 2) and 1 case with supraclavicular LNs. It downstaged 3 cases with ipsilateral mediastinal LNs. In each group, there were cases with no overall change in stage due to other findings.
According to M staging
Regarding contralateral pulmonary nodules detected only by CT, all the six cases showed no change in overall staging and were still staged as M1c due to the presence of distant metastasis.
Pleural effusions are common in patients with NSCLC. Many of these pleural effusions are benign and may represent benign reactive fluid collections that do not preclude curative surgery. Thus, it is important to accurately differentiate benign from malignant effusion [25].
This study agrees with Schaffler et al. [26] who reported that that PET-CT is a good tool for differentiation between benign and malignant pleural effusion. In this study, PET/CT downstaged only one case from M1a to M0 as the pleural effusion was not FDG avid, while the remaining cases showed no change in M stage due to the presence of distant metastasis.
In routine clinical practice, CT remains the standard imaging technique for the liver. The use of PET is mainly to provide additional information for the differentiation of hepatic lesions that are indeterminate on conventional imaging [27].
This study agrees with Stroobants [27] that PET-CT provides additional information for the characterization of hepatic lesions detected by CT. PET/CT led to downstaging of two cases, one of them was downstaged from M1b to M0 and from IVA to IB rendering the patient operable, yet the bad general condition of the patient precluded surgery. The other case was downstaged from M1b to M1a, but the overall stage was not changed (IVA) due to the associated contralateral pulmonary nodules.
Regarding adrenal metastasis, Fangfang and Hong [28] showed that in patients with NSCLC, many solitary adrenal masses were not malignant. So, it is very critical to distinguish between a metastatic lesion and an adenoma.
In this study, PET/CT upstaged only one case from M0 to M1b and from IIIc to IV A after detecting high FDG uptake in the adrenal gland (Fig. 3).
Regarding brain metastasis, in this study, only two cases had brain metastasis by CT and were identified easily by PET-CT because of the good anatomical localization applied by CT. This study agrees with Fangfang and Hong [28] and Patricia et al. [29] that CT and/or MRI are more sensitive than PET/CT in detecting brain metastasis. So, there was no change in the staging regarding brain metastasis in this study.
Regarding bone metastasis, in the current study, we agree with Silvestri et al. [6], Wu et al. [30], and Schirrmeister et al. [31] studies who concluded that PET-CT is effective in detecting bone metastasis. In this study, PET/CT upstaged 4 cases from M0 and M1a to M1b but two cases showed no change due to associated extrathoracic metastasis (Fig. 4).
Regarding intramuscular metastasis, this study agrees with Surov et al. [32], Yilmaz et al. [33], and Savas et al. [34] who reported high sensitivity and specificity of PET/CT to detect intramuscular metastasis in comparison to CT alone. In the current study, the three cases detected by PET/CT only showed no change in the overall staging due to associated distant metastasis.
Regarding the extrathoracic LNs, FDG PET/CT may be used to identify unsuspected metastases. PET/CT may be used to identify metastases in normal-sized lymph nodes (< 1 cm at CT), as well as in those with a fatty hilum. Nodal uptake of FDG that is higher than the FDG uptake in the blood pool is suspicious for nodal metastases, and nodal uptake of FDG that is higher than the liver uptake of FDG is highly suspicious for nodal metastases [11].
The current study is in keeping with Sahiner and Vural [35], who reported that the use of PET/CT can also reveal metastasis that would otherwise escape detection as lymph nodes. The benefit of combining conventional CT with PET imaging has been estimated to increase the odds of identifying metastasis at those uncommon sites by 5–29%. The four cases detected by PET/CT showed no change in the overall staging due to associated liver and bone metastasis.
In the current study, PET-CT changed the plan of treatment in 5 patients. So, we agree with El-Hariri et al. [36] and Subedi et al. [37] who reported the impact of PET/CT on changing the stage of the disease and the treatment strategy with change in the management plan converting some operable patients to being inoperable and vice versa.
The study had several limitations. The relatively smaller sample size compared to other studies on the same topic. Most of cases were presented in the delayed stages of the disease with multiple distant metastasis, so there was no role for surgery in these cases and no need for further diagnostic imaging or histopathological correlation.